High mobility group box 1 protein (HMGB1) is increasingly regarded as an important player
in the spinal regulation of chronic pain. Although it has been reported that HMGB1 induces …

We have previously demonstrated that glial inhibitors reduce the development of allodynia
and hyperalgesia, potentiating the effect of a single morphine dose in a neuropathic pain …

Background Recent studies have implicated the activation of stress-activated mitogen-
activated protein kinase (MAPK) p38 in spinal microglial cells for development of …

Activation of spinal cord microglia and astrocytes is a common phenomenon in nerve injury
pain models and is thought to exacerbate pain perception. Following a nerve injury, a …

With a widespread opioid epidemic and profound biopsychosocial implications, chronic pain
is a multifaceted public health issue requiring urgent attention. The treatment of chronic pain …

Modern cancer therapies have significantly increased patient survival rates in both human
and veterinary medicine. Since cancer patients live longer they now face new challenges …

During spinal cord injury (SCI), a quick and sustained decline of Neuregulin-1 (Nrg1) has
been observed, exerting a significant positive effect in modulating the proliferation of …

Background The pro-nociceptive kinin B 1 receptor (B 1 R) is upregulated on sensory C-
fibres, astrocytes and microglia in the spinal cord of streptozotocin (STZ)-diabetic rat. This …

Abstract Background Aconiti brachypodi Radix (Xue-shang-yi-zhi-hao) has been prescribed
to manage chronic pain, arthritis, and traumatic injuries. Bullatine A, a C 20-diterpenoid …

Neuropathic pain is an intractable clinical problem, affecting millions of people worldwide.
Preemptive administration of minocycline has been confirmed useful for treating neuropathic …