The chronicity of pain is the feature of pain that is least understood and most directly linked
with our inability to effectively manage pain. Acute pain is relatively responsive to our current …

Previous studies have suggested that the release of brain‐derived neurotrophic factor
(BDNF) from microglia in spinal cord is necessary for maintaining pain hypersensitivity after …

Background The cellular and molecular pathophysiological mecha\nisms of pain processing
in neglected parasitic infections such as leishmaniasis remain unknown. The present study …

Background and Objectives: Recent studies have suggested that nuclear factor κB (NF-κB)
may play a role in mediating nerve injury-induced neuropathic pain. Here, we examined the …

Neuropathic pain is a refractory clinical problem. Certain drugs, such as tramadol, proved
useful for the treatment of neuropathic pain by inhibiting the activity of nociceptive neurons …

Minocycline, a glial suppressor, prevents behavioral hypersensitivities in animal models of
peripheral nerve injury. However, clinical trials of minocycline in human studies have …

There is increasing evidence that the relationship between chronic pain and infections is
complex and intertwined. Bacterial and viral infections can cause pain through numerous …

The aim of the present study was to investigate the role of the amygdala in the potentiative
effect of minocycline, a semisynthetic tetracycline antibiotic, on morphine analgesia in male …

Neuropathic pain is a severe and chronic neurological disease caused by injury or disease
of the somatosensory system. Currently, there are no effective treatments for neuropathic …

Objective: Peripheral nerve block guidance with a nerve stimulator or echo may not prevent
intrafascicular injury. This study investigated whether intrafascicular lidocaine induces …