Botulinum neurotoxins in central nervous system: An overview from animal models to human therapy

S Luvisetto - Toxins, 2021 - mdpi.com
Botulinum neurotoxins (BoNTs) are potent inhibitors of synaptic vesicle fusion and
transmitter release. The natural target of BoNTs is the peripheral neuromuscular junction …

Treatment of depression with botulinum toxin

MA Wollmer, M Magid, THC Kruger, E Finzi - Toxins, 2022 - mdpi.com
Injection of botulinum toxin (BoNT) into the glabellar region of the face is a novel therapeutic
approach in the treatment of depression. This treatment method has several advantages …

Postmarketing safety surveillance data reveals protective effects of botulinum toxin injections against incident anxiety

MA Wollmer, T Makunts, THC Krüger, R Abagyan - Scientific reports, 2021 - nature.com
Randomized controlled trials (RCTs) have shown an antidepressant effect of glabellar
botulinum toxin (BoNT) injections. In the FDA Adverse Event Reporting System (FAERS) …

Ranitidine alleviates anxiety-like behaviors and improves the density of pyramidal neurons upon deactivation of microglia in the CA3 region of the hippocampus in a …

DB Selvaraj, JF Vergil Andrews, M Anusuyadevi… - Brain Sciences, 2023 - mdpi.com
Elevated levels of histamine cause over-secretion of gastric hydrochloric acid (HCl), leading
to gastrointestinal (GI) disorders and anxiety. Ranitidine is an antihistamine drug widely …

Clinical efficacy of escitalopram combined with botulinum toxin A in patients with generalized anxiety disorder and comorbid headache

Y Wang, X Yang, X Ji, M Liu, C Zhou - Psychopharmacology, 2023 - Springer
Background Generalized anxiety disorder (GAD) is a common mental disorder that happens
comorbidly with other diseases. Headache is a common anxiety comorbidity. Previous …

Omeprazole treatment manifests anxiolytic effects in a cysteamine hydrochloride induced mouse model of gastrointestinal disorder

HS Rethinavel, DB Selvaraj, SJ Balakrishnan… - Heliyon, 2022 - cell.com
Omeprazole, a proton pump inhibitor (PPI), has widely been used to treat various
gastrointestinal (GI) disorders. Notably, many clinical symptoms of GI disorders have been …

The mind body connection in dermatologic conditions: A literature review

K Mar, JK Rivers - Journal of Cutaneous Medicine and …, 2023 - journals.sagepub.com
Psychodermatology pertains to the relationship between the skin and brain. This review
aims to summarize the evidence of the mind body connection in four psychophysiological …

[HTML][HTML] Low-dose aspirin increases olfactory sensitivity in association with enhanced neurogenesis and reduced activity of AChE in the experimental aging mice

JFV Andrews, DB Selvaraj, AB Radhakrishnan… - Medicine in Drug …, 2024 - Elsevier
This study examined the effect of aspirin on olfactory discrimination and neurogenesis in
experimental aging mice. The results from the buried food test (BFT) and odour preference …

Single injection of very mild dose botulinum toxin in the vastus lateralis improves testicular spermatogenesis and sperm motility in ageing experimental mice

RK Radhakrishnan, S Ravichandran, A Sukesh… - Laboratory animal …, 2022 - Springer
Abstract Background Botulinum toxin (BoNT) is a widely used therapeutic agent that blocks
the excessive release of acetylcholine at the neuromuscular junction. Previously, repeated …

[PDF][PDF] Treatment of Depression with Botulinum Toxin. Toxins 2022, 14, 383

MA Wollmer, M Magid, THC Kruger, E Finzi - 2022 - researchgate.net
Injection of botulinum toxin (BoNT) into the glabellar region of the face is a novel therapeutic
approach in the treatment of depression. This treatment method has several advantages …