The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and …

DB Kell, E Pretorius - Biochemical Journal, 2022 - portlandpress.com
Ischaemia–reperfusion (I–R) injury, initiated via bursts of reactive oxygen species produced
during the reoxygenation phase following hypoxia, is well known in a variety of acute …

Recent trends in targeted delivery of smart nanocarrier-based microbial enzymes for therapeutic applications

N Jangra, A Kawatra, B Datten, S Gupta, P Gulati - Drug Discovery Today, 2024 - Elsevier
Smart carrier-based immobilization has widened the use of enzymes for the treatment of
several disorders. Large surface areas, tunable morphology, and surface modification ability …

[HTML][HTML] Therapeutic and anti-thrombotic properties of some naturally fermented soybean foods of the Eastern Himalayas

P Kharnaior, M Das, JP Tamang - Fermentation, 2023 - mdpi.com
Naturally fermented soybean foods have anti-thrombotic properties due to the presence of
microbial fibrinolytic enzymes. However, fibrinolytic enzyme-producing bacteria from …

Evaluation of the antioxidant, thrombolytic, and antimicrobial effects of Corchorus aestuans L. leaf extracts: an in-vitro and in-silico study

N Jannat, K Fatema, MA Haque, J Fatema… - South African Journal of …, 2024 - Elsevier
Abstract Corchorus aestuans L.(Malvaceae), a little annual plant, grows in wastelands at low
and medium altitudes. It has traditionally been used as an antihistaminic, anti-inflammatory …

[HTML][HTML] The Conservation and Study of Macromycetes in the Komarov Botanical Institute Basidiomycetes Culture Collection—Their Taxonomical Diversity and …

NV Psurtseva, AA Kiyashko, SV Senik, NV Shakhova… - Journal of Fungi, 2023 - mdpi.com
Culture collections (CCs) play an important role in the ex situ conservation of biological
material and maintaining species and strains, which can be used for scientific and practical …

Split intein-mediated backbone cyclization enhances the stability and activity of staphylokinase, a potent fibrin-selective plasminogen activator

A Baharian, H Ishida, C Sillner, HJ Vogel - International Journal of …, 2024 - Elsevier
Abstract Staphylokinase (Sak), a small 15 kDa globular protein that is secreted by certain
strains of Staphylococcus aureus, shows a potent fibrin-selective thrombolytic activity. Earlier …

Automated microscopic measurement of fibrinaloid microclots and their degradation by nattokinase, the main natto protease

JM Grixti, CW Theron, JE Salcedo-Sora, E Pretorius… - bioRxiv, 2024 - biorxiv.org
Nattokinase, from the Japanese fermented food natto, is a protease with fibrinolytic activity
that can thus degrade conventional blood clots. In some cases, however, including in Long …

ROS-responsive phenylboronic ester-based nanovesicles as multifunctional drug delivery systems for the treatment of inflammatory and thrombotic complications

Y Xia, R Chen, Y Ke, Q Han, Z Ma, Q Shi - Biomaterials Science, 2023 - pubs.rsc.org
Inflammatory and thrombotic complications and a low loading of dual drugs with different
hydrophilicities remain challenges to treat thrombosis with drug delivery systems (DDSs) …

Fibrinogen binding to activated platelets and its biomimetic thrombus-targeted thrombolytic strategies

Y Huang, J Wang, Y Guo, L Shen, Y Li - International Journal of Biological …, 2024 - Elsevier
Thrombosis is associated with various fatal arteriovenous syndromes including ischemic
stroke, myocardial infarction, and pulmonary embolism. However, current clinical …

In vitro assessment of thrombolytic potential of red and white ginger (Zingiber officinale)

R Pinontoan, PAI Leke, JA Lesmana… - Functional Foods in …, 2024 - ffhdj.com
Background: Cardiovascular diseases (CVDs) are a leading cause of death, and their
pathogenesis is commonly attributed to thrombosis. Although existing medications are …