[HTML][HTML] Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence

X Liu, Y Liu, J Liu, H Zhang, C Shan… - Neural Regeneration …, 2024 - journals.lww.com
A growing body of evidence suggests that the gut microbiota contributes to the development
of neurodegenerative diseases via the microbiota-gut-brain axis. As a contributing factor …

[HTML][HTML] Status of metabolomic measurement for insights in Alzheimer's disease progression—What is missing?

C Yin, AC Harms, T Hankemeier, A Kindt… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is an aging-related neurodegenerative disease, leading to the
progressive loss of memory and other cognitive functions. As there is still no cure for AD, the …

Predicting neurodegenerative disease using prepathology gut microbiota composition: a longitudinal study in mice modeling Alzheimer's disease pathologies

EM Borsom, K Conn, CR Keefe, C Herman… - Microbiology …, 2023 - Am Soc Microbiol
The gut microbiota-brain axis is suspected to contribute to the development of Alzheimer's
disease (AD), a neurodegenerative disease characterized by amyloid-β plaque deposition …

Multi-omics data reveals aberrant gut microbiota-host glycerophospholipid metabolism in association with neuroinflammation in APP/PS1 mice

X Qian, W Hai, S Chen, M Zhang, X Jiang, H Tang - Gut Microbes, 2023 - Taylor & Francis
Numerous studies have described the notable impact of gut microbiota on the brain in
Alzheimer's disease (AD) via the gut–brain axis. However, the molecular mechanisms …

[HTML][HTML] Influence of complement protein C1q or complement receptor C5aR1 on gut microbiota composition in wildtype and Alzheimer's mouse models

TJ Petrisko, M Gargus, SH Chu, P Selvan… - Journal of …, 2023 - Springer
The contribution of the gut microbiome to neuroinflammation, cognition, and Alzheimer's
disease progression has been highlighted over the past few years. Additionally, inhibition of …

[HTML][HTML] Gut-derived metabolites mediating cognitive development in 5-year-old children: early-life transplant in mice has lasting effects throughout adulthood

MA Guzzardi, F La Rosa, F Granziera, D Panetta… - Brain, Behavior, and …, 2023 - Elsevier
The gut microbiota has been causally linked to cognitive development. We aimed to identify
metabolites mediating its effect on cognitive development, and foods or nutrients related to …

[HTML][HTML] Epigallocatechin-3-Gallate and Genistein for Decreasing Gut Dysbiosis, Inhibiting Inflammasomes, and Aiding Autophagy in Alzheimer's Disease

A Muraleedharan, SK Ray - Brain Sciences, 2024 - mdpi.com
There are approximately 24 million cases of Alzheimer's disease (AD) worldwide, and the
number of cases is expected to increase four-fold by 2050. AD is a neurodegenerative …

Modulation of Alzheimer's disease brain pathology in mice by gut bacterial depletion: the role of IL-17a

W Hao, Q Luo, I Tomic, W Quan, T Hartmann… - Gut …, 2024 - Taylor & Francis
Gut bacteria regulate brain pathology of Alzheimer's disease (AD) patients and animal
models; however, the underlying mechanism remains unclear. In this study, 3-month-old …

Implications of microbe-derived ɣ-aminobutyric acid (GABA) in gut and brain barrier integrity and GABAergic signaling in Alzheimer's disease

KA Conn, EM Borsom, EK Cope - Gut Microbes, 2024 - Taylor & Francis
The gut microbial ecosystem communicates bidirectionally with the brain in what is known
as the gut-microbiome-brain axis. Bidirectional signaling occurs through several pathways …

Empagliflozin alleviates neuroinflammation by inhibiting astrocyte activation in the brain and regulating gut microbiota of high-fat diet mice

Q Huang, L Liu, X Tan, S Wang, S Wang, J Luo… - Journal of Affective …, 2024 - Elsevier
A high-fat diet can modify the composition of gut microbiota, resulting in dysbiosis. Changes
in gut microbiota composition can lead to increased permeability of the gut barrier, allowing …