[HTML][HTML] Implementing New Approach Methodologies (NAMs) in food safety assessments: Strategic objectives and actions taken by the European Food Safety …
I Cattaneo, MC Astuto, M Binaglia, Y Devos… - Trends in Food Science …, 2023 - Elsevier
Abstract Background New Approach Methodologies (NAMs) comprise in silico and in vitro
methods applied as alternative to animal testing. Even though NAMs are already fully …
methods applied as alternative to animal testing. Even though NAMs are already fully …
Drug-drug interactions that alter the exposure of glucuronidated drugs: Scope, UDP-glucuronosyltransferase (UGT) enzyme selectivity, mechanisms (inhibition and …
Drug-drug interactions (DDIs) arising from the perturbation of drug metabolising enzyme
activities represent both a clinical problem and a potential economic loss for the …
activities represent both a clinical problem and a potential economic loss for the …
Development of a roadmap for action on new approach methodologies in risk assessment
SE Escher, F Partosch, S Konzok… - EFSA Supporting …, 2022 - Wiley Online Library
While whole animal studies have their place in risk assessment of food and feed
components, it is thought that more modern approaches such as human focused new …
components, it is thought that more modern approaches such as human focused new …
Inhibition of UDP-glucuronosyltransferase enzymes by major cannabinoids and their metabolites
The UDP-glucuronosyltransferase (UGT) family of enzymes play a central role in the
metabolism and detoxification of a wide range of endogenous and exogenous compounds …
metabolism and detoxification of a wide range of endogenous and exogenous compounds …
[HTML][HTML] Human variability in polymorphic CYP2D6 metabolism: Implications for the risk assessment of chemicals in food and emerging designer drugs
The major human cytochrome P450 CYP2D6 isoform enzyme plays important roles in the
liver and in the brain with regards to xenobiotic metabolism. Xenobiotics as CYP2D6 …
liver and in the brain with regards to xenobiotic metabolism. Xenobiotics as CYP2D6 …
Drug metabolism of hepatocyte-like organoids and their applicability in in vitro toxicity testing
MC Bouwmeester, Y Tao, S Proença… - Molecules, 2023 - mdpi.com
Emerging advances in the field of in vitro toxicity testing attempt to meet the need for reliable
human-based safety assessment in drug development. Intrahepatic cholangiocyte …
human-based safety assessment in drug development. Intrahepatic cholangiocyte …
[HTML][HTML] Human variability in glutathione-S-transferase activities, tissue distribution and major polymorphic variants: Meta-analysis and implication for chemical risk …
The input into the QIVIVE and Physiologically-Based kinetic and dynamic models of drug
metabolising enzymes performance and their inter-individual differences significantly …
metabolising enzymes performance and their inter-individual differences significantly …
Modelling human variability in toxicokinetic and toxicodynamic processes using Bayesian meta‐analysis, physiologically‐based modelling and in vitro systems
E Testai, C Bechaux, FM Buratti… - EFSA Supporting …, 2021 - Wiley Online Library
This external scientific report summarises the results from thearticle 36 grant
GA/EFSA/SCER/2015/01 ″Modelling human variability in toxicokinetic and toxicodynamic …
GA/EFSA/SCER/2015/01 ″Modelling human variability in toxicokinetic and toxicodynamic …
Stratification of volunteers according to flavanone metabolite excretion and phase ii metabolism profile after single doses of 'pera'orange and 'moro'blood orange …
A Nishioka, EC Tobaruela, LN Fraga… - Nutrients, 2021 - mdpi.com
Large interindividual variations in the biological response to citrus flavanones have been
observed, and this could be associated with high variations in their bioavailability. The aim …
observed, and this could be associated with high variations in their bioavailability. The aim …
PBPK modeling as a tool for predicting and understanding intestinal metabolism of uridine 5′-Diphospho-glucuronosyltransferase substrates
MB Reddy, MB Bolger, G Fraczkiewicz, L Del Frari… - Pharmaceutics, 2021 - mdpi.com
Uridine 5′-diphospho-glucuronosyltransferases (UGTs) are expressed in the small
intestines, but prediction of first-pass extraction from the related metabolism is not well …
intestines, but prediction of first-pass extraction from the related metabolism is not well …