Neurons as stromal drivers of nervous system cancer formation and progression

C Anastasaki, Y Gao, DH Gutmann - Developmental cell, 2023 - cell.com
Similar to their pivotal roles in nervous system development, neurons have emerged as
critical regulators of cancer initiation, maintenance, and progression. Focusing on nervous …

Ion channel involvement in tumor drug resistance

C Altamura, P Gavazzo, M Pusch… - Journal of personalized …, 2022 - mdpi.com
Over 90% of deaths in cancer patients are attributed to tumor drug resistance. Resistance to
therapeutic agents can be due to an innate property of cancer cells or can be acquired …

Unexplained Causes of Glioma-Associated Epilepsies: A Review of Theories and an Area for Research

M Saviuk, E Sleptsova, T Redkin, V Turubanova - Cancers, 2023 - mdpi.com
Simple Summary Patients with gliomas experience worsened quality of life due to epileptic
attacks. Over 80% of patients are susceptible to seizures, significantly hindering their …

Glioma‑neuronal interactions in tumor progression: Mechanism, therapeutic strategies and perspectives

T Hua, H Shi, M Zhu, C Chen, Y Su… - International …, 2022 - spandidos-publications.com
An increasing body of evidence has become available to reveal the synaptic and functional
integration of glioma into the brain network, facilitating tumor progression. The novel …

The complexities underlying epilepsy in people with glioblastoma

E Sokolov, J Dietrich, AJ Cole - The Lancet Neurology, 2023 - thelancet.com
Seizures are among the most common clinical signs in people with glioblastoma. Advances
over the past 5 years, including new clinical trial data, have increased the understanding of …

Ion channels in gliomas—from molecular basis to treatment

AF Elias, BC Lin, BJ Piggott - International Journal of Molecular Sciences, 2023 - mdpi.com
Ion channels provide the basis for the nervous system's intrinsic electrical activity. Neuronal
excitability is a characteristic property of neurons and is critical for all functions of the …

Role of the voltage‑gated sodium channel Nav1. 6 in glioma and candidate drugs screening

Y Ai, X Zhang, X Hu, J Gao, J Liu… - International …, 2023 - spandidos-publications.com
Gliomas remain a clinical challenge, common and fatal. Treatment of glioblastoma remains
elusive, and researchers have focused on discovering new mechanisms and drugs. It has …

Development of an integrated predictive model for postoperative glioma-related epilepsy using gene-signature and clinical data

L Li, C Zhang, Z Wang, Y Wang, Y Guo, C Qi, G You… - BMC cancer, 2023 - Springer
Background This study aimed to develop an integrated model for predicting the occurrence
of postoperative seizures in patients with diffuse high-grade gliomas (DHGGs) using clinical …

Identification of KCNK1 as a potential prognostic biomarker and therapeutic target of breast cancer

X Sun, Y Li, H Lan, T Jiang, X Wan, Y Cheng - Pathology-Research and …, 2023 - Elsevier
Background Breast cancer is the most common malignant cancer and is the second most
common cause of cancer-related deaths among females worldwide. Thus, it warrants the …

Roles of TRPM channels in glioma

Z Chen, H Xie, J Liu, JJ Zhao, R Huang… - Cancer Biology & …, 2024 - Taylor & Francis
Gliomas are the most common type of primary brain tumor. Despite advances in treatment, it
remains one of the most aggressive and deadly tumor of the central nervous system (CNS) …