Eighteen nucleic acid therapeutics have been approved for treatment of various diseases in
the last 25 years. Their modes of action include antisense oligonucleotides (ASOs), splice …

Quadruplex-forming sequences are widely prevalent in human and other genomes,
including bacterial ones. These sequences are over-represented in eukaryotic telomeres …

Abstract RNA G-quadruplexes (G4s) are formed by G-rich RNA sequences in protein-coding
(mRNA) and non-coding (ncRNA) transcripts that fold into a four-stranded conformation …

Phen‐DC3 is a highly promising compound that specifically targets G‐quadruplexes, with
potent biological effects observed in vivo. We used NMR spectroscopy to solve the structure …

Tetra-substituted naphthalene diimide (ND) derivatives with positively charged termini are
potent stabilizers of human telomeric and gene promoter DNA quadruplexes and inhibit the …

Designing ligands targeting G-quadruplex nucleic acid structures and affecting cellular
processes is complicated because there are multiple target sequences and some are …

G-quadruplexes (G4s) are higher-order DNA structures typically present at promoter regions
of genes and telomeres. Here, the G4 formation decreases the replicative DNA at each cell …

Nucleic acid mimics of fluorescent proteins can be valuable tools to locate and image
functional biomolecules in cells. Stacking between the internal G-quartet, formed in the …

The formation of G-quadruplex structures (G4s) in vitro from guanine (G)-rich nucleic acid
sequences of DNA and RNA stabilized with monovalent cations, typically K+ and Na+, under …

DNA three-way junction (TWJ) structures transiently form during key cellular processes such
as transcription, replication, and DNA repair. Despite their significance, the thermodynamics …