Alcohol use produces wide-ranging and diverse effects on the central nervous system. It
influences intracellular signaling mechanisms, leading to changes in gene expression …

The Neurobiology of Adolescent Drinking in Adulthood (NADIA) Consortium has focused on
the impact of adolescent binge drinking on brain development, particularly on effects that …

Alcoholism is a complex brain disease characterized by three distinct stages of the addiction
cycle that manifest as neuroadaptive changes in the brain. One such stage of the addiction …

Advances achieved with molecular biology and genomics technologies have permitted
investigators to discover epigenetic mechanisms, such as DNA methylation and histone …

Studies universally find early age of drinking onset is linked to lifelong risks of alcohol
problems and alcohol use disorder (AUD). Assessment of the lasting effect of drinking during …

Evidence obtained in recent decades has demonstrated that the brain still matures in
adolescence. Changes in neural connectivity occur in different regions, including cortical …

Although both humans and laboratory rodents demonstrate cognitive and affective
alterations associated with adolescent alcohol exposure, it is still unknown whether the …

Stress-related disorders, such as anxiety, early life stress, and posttraumatic stress disorder
appear to be important factors in promoting alcoholism, as alcohol consumption can …

Alcohol use disorder (AUD) is a complex brain disorder with an array of persistent
behavioral and neurochemical manifestations. Both genetic and environmental factors are …

Adolescent alcohol drinking is known to contribute to the development and severity of
alcohol use disorders (AUDs) later in adulthood. Recent studies have shown that long non …