Antibiotic resistance in Pseudomonas aeruginosa–Mechanisms, epidemiology and evolution

J Botelho, F Grosso, L Peixe - Drug resistance updates, 2019 - Elsevier
Antibiotics are powerful drugs used in the treatment of bacterial infections. The inappropriate
use of these medicines has driven the dissemination of antibiotic resistance (AR) in most …

[HTML][HTML] Role of Efflux Pumps on Antimicrobial Resistance in Pseudomonas aeruginosa

AB Lorusso, JA Carrara, CDN Barroso, FF Tuon… - International Journal of …, 2022 - mdpi.com
Antimicrobial resistance is an old and silent pandemic. Resistant organisms emerge in
parallel with new antibiotics, leading to a major global public health crisis over time …

[HTML][HTML] Pseudomonas aeruginosa: Infections, Animal Modeling, and Therapeutics

SJ Wood, TM Kuzel, SH Shafikhani - Cells, 2023 - mdpi.com
Pseudomonas aeruginosa is an important Gram-negative opportunistic pathogen which
causes many severe acute and chronic infections with high morbidity, and mortality rates as …

The Pseudomonas aeruginosa Pan-Genome Provides New Insights on Its Population Structure, Horizontal Gene Transfer, and Pathogenicity

L Freschi, AT Vincent, J Jeukens… - Genome biology and …, 2019 - academic.oup.com
The huge increase in the availability of bacterial genomes led us to a point in which we can
investigate and query pan-genomes, for example, the full set of genes of a given bacterial …

[HTML][HTML] Genomic and Metabolic Characteristics of the Pathogenicity in Pseudomonas aeruginosa

T De Sousa, M Hébraud, MLNE Dapkevicius… - International journal of …, 2021 - mdpi.com
In recent years, the effectiveness of antimicrobials in the treatment of Pseudomonas
aeruginosa infections has gradually decreased. This pathogen can be observed in several …

[HTML][HTML] Pseudomonas aeruginosa reference strains PAO1 and PA14: A genomic, phenotypic, and therapeutic review

A Grace, R Sahu, DR Owen, VA Dennis - Frontiers in Microbiology, 2022 - frontiersin.org
Pseudomonas aeruginosa is a ubiquitous, motile, gram-negative bacterium that has been
recently identified as a multi-drug resistant pathogen in critical need of novel therapeutics. Of …

Genome‐based evolutionary history of Pseudomonas spp

C Hesse, F Schulz, CT Bull, BT Shaffer… - Environmental …, 2018 - Wiley Online Library
Pseudomonas is a large and diverse genus of Gammaproteobacteria. To provide a
framework for discovery of evolutionary and taxonomic relationships of these bacteria, we …

[HTML][HTML] Global emergence of the widespread Pseudomonas aeruginosa ST235 clone

P Treepong, VN Kos, C Guyeux, DS Blanc… - Clinical Microbiology …, 2018 - Elsevier
Objectives Despite the non-clonal epidemic population structure of Pseudomonas
aeruginosa, several multi-locus sequence types are distributed worldwide and are …

Pseudomonas aeruginosa and microbial keratitis

Y Hilliam, S Kaye, C Winstanley - Journal of medical …, 2020 - microbiologyresearch.org
Pseudomonas aeruginosa, a versatile Gram-negative pathogen that can cause a wide
range of infections, is the most common causative agent in cases of bacterial keratitis …

First steps in the analysis of prokaryotic pan-genomes

SS Costa, LC Guimarães, A Silva… - … and Biology Insights, 2020 - journals.sagepub.com
Pan-genome is defined as the set of orthologous and unique genes of a specific group of
organisms. The pan-genome is composed by the core genome, accessory genome, and …