Axons are electrically excitable, cable-like neuronal processes that relay information
between neurons within the nervous system and between neurons and peripheral target …

In recent years, research on sphingolipids, particularly ceramides, has attracted increased
attention, revealing the important roles and many functions of these molecules in several …

Sphingolipid imbalance is the culprit in a variety of neurological diseases, some affecting the
myelin sheath. We have used whole-exome sequencing in patients with undetermined …

Background Over 80% of women with X-linked adrenoleukodystrophy (ALD) develop spinal
cord disease in adulthood for which treatment is supportive only. For future clinical trials …

Idiosyncratic drug-induced liver injury (IDILI) is a rare but potentially severe adverse drug
reaction. To date, identifying individuals at risk for IDILI remains challenging. This is a …

X-linked adrenoleukodystrophy is caused by ATP-binding cassette transporter D1 (ABCD1)
mutations and manifests by default as slowly progressive spinal cord axonopathy with …

Abstract X-Adrenoleukodystrophy (X-ALD) and its adult-onset, most prevalent variant
adrenomyeloneuropathy (AMN) are caused by mutations in the peroxisomal transporter of …

The nuclear factor erythroid 2‐like 2 (NRF 2) is the master regulator of endogenous
antioxidant responses. Oxidative damage is a shared and early‐appearing feature in X …

Methods Data for this review was identified through a literature search using PubMed,
Google Scholar, and personal repositories of articles collected by the authors. Findings are …

The activation of the highly conserved unfolded protein response (UPR) is prominent in the
pathogenesis of the most prevalent neurodegenerative disorders, such as Alzheimer's …