Simple Summary Despite being in use for almost 50 years, monoclonal antibodies face
limitations in their implementation in clinical practice, particularly in pediatrics and pediatric …

Disialoganglioside GD2 is a promising target for immunotherapy with expression primarily
restricted to neuroectodermal and epithelial tumor cells. Although its role in the maintenance …

Abstract Background Beta-1, 3-galactosyltransferase-4 (B3GALT4) plays a critical regulatory
role in tumor biology. However, the role of B3GALT4 in modulating the tumor …

Simple Summary Molecular analyses discussed in Molecular Tumor Boards are expected to
improve cancer treatment by identifying tumor-specific alterations. Here, we quantified the …

Background Neuroblastoma (NB) is the most frequent solid tumor in pediatrics, which
accounts for roughly 15% of cancer-related mortality in children. NB exhibited genetic …

Introduction Gangliosides play an essential role in cancer development and progression.
However, the involvement of gangliosides in the prognosis and tumor microenvironment …

Neuroblastoma (NB) is an extracranial solid tumor in children with poor prognosis in high-
risk patients and its pathogenesis and prognostic markers urgently need to be explored. This …

The major liver cancer subtype is hepatocellular carcinoma (HCC). Studies have indicated
that a better prognosis is related to the presence of tumor-infiltrating lymphocytes (TILs) in …

Abstract Purpose of Review Neuroblastoma is the most commonly seen extracranial tumor
in children originating from the sympathetic nervous system. It is responsible for …

Neuroblastoma (NBL) and medulloblastoma (MB) are aggressive pediatric cancers which
can benefit from therapies targeting gangliosides. Therefore, we compared the ganglioside …