Rheumatoid arthritis (RA) is characterized by inflammation and destruction of bone and
cartilage in affected joints. Autoimmune responses lead to increased osteoclastic bone …

Rheumatoid arthritis is a heterogeneous disease, which can be, based on data combining
genetic risk factors and autoantibodies, sub-classified into ACPA-positive and-negative RA …

Background: Rheumatoid arthritis is a chronic disabling disease characterized by chronic
inflammation, articular cartilage destruction, and reduced bone mass. Multiple studies have …

Rheumatoid arthritis is a chronic autoimmune disease that causes progressive articular
damage, functional loss, and comorbidity. The development of effective biologics and small …

Objectives Rheumatoid arthritis (RA)-specific anti-citrullinated protein/peptide antibodies
(ACPAs) appear before disease onset and are associated with bone destruction. We aimed …

Rheumatoid arthritis (RA) is a chronic autoimmune disease considered as a multistep
process spanning from the interaction of genetic (eg, shared epitope or non-HLA loci) …

Rheumatoid arthritis is a chronic autoimmune syndrome associated with several genetic,
epigenetic, and environmental factors affecting the articular joints contributing to cartilage …

A key unanswered question in the pathophysiology of rheumatoid arthritis (RA) is how
systemic autoimmunity progresses to joint-specific inflammation. In patients with seropositive …

Osteoporosis has been classically considered a comorbidity of rheumatoid arthritis (RA).
However, recent advances in the pathogenesis of osteoporosis in RA have shown a close …

Over the past several years, a pathophysiological role for the IL-23–IL-17 pathway in human
disease has been defined. A subset of rheumatic diseases, including psoriatic arthritis (PsA) …