Deplete and repeat: microglial CSF1R inhibition and traumatic brain injury
R Boland, ON Kokiko-Cochran - Frontiers in Cellular Neuroscience, 2024 - frontiersin.org
Traumatic brain injury (TBI) is a public health burden affecting millions of people. Sustained
neuroinflammation after TBI is often associated with poor outcome. As a result, increased …
neuroinflammation after TBI is often associated with poor outcome. As a result, increased …
[HTML][HTML] Diffusion tensor imaging and plasma immunological biomarker panel in a rat traumatic brain injury (TBI) model and in human clinical TBI
XV To, AZ Mohamed, P Cumming… - Frontiers in …, 2024 - frontiersin.org
Introduction Neuroinflammatory reactions play a significant role in the pathology and long-
term consequences of traumatic brain injury (TBI) and may mediate salutogenic processes …
term consequences of traumatic brain injury (TBI) and may mediate salutogenic processes …
[HTML][HTML] Wide-field calcium imaging reveals widespread changes in cortical functional connectivity following mild traumatic brain injury in the mouse
SW Cramer, SP Haley, LS Popa, RE Carter… - Neurobiology of …, 2023 - Elsevier
2.5 million individuals in the United States suffer mild traumatic brain injuries (mTBI)
annually. Mild TBI is characterized by a brief period of altered consciousness, without …
annually. Mild TBI is characterized by a brief period of altered consciousness, without …
A single closed head injury in male adult mice induces chronic, progressive white matter atrophy and increased phospho-tau expressing oligodendrocytes
DF Havlicek, R Furhang, E Nikulina… - Experimental …, 2023 - Elsevier
Traumatic brain injury (TBI) acutely damages the brain; this injury can evolve into chronic
neurodegeneration. While much is known about the chronic effects arising from multiple mild …
neurodegeneration. While much is known about the chronic effects arising from multiple mild …
Escalation of tau accumulation after a traumatic brain injury: findings from positron emission tomography
Traumatic brain injury (TBI) has come to be recognized as a risk factor for Alzheimer's
disease (AD), with poorly understood underlying mechanisms. We hypothesized that a …
disease (AD), with poorly understood underlying mechanisms. We hypothesized that a …
Subacute cytokine changes after a traumatic brain injury predict chronic brain microstructural alterations on advanced diffusion imaging in the male rat
Introduction The process of neuroinflammation occurring after traumatic brain injury (TBI)
has received significant attention as a potential prognostic indicator and interventional target …
has received significant attention as a potential prognostic indicator and interventional target …
An end-end deep learning framework for lesion segmentation on multi-contrast mr images—an exploratory study in a rat model of traumatic brain injury
Traumatic brain injury (TBI) engenders traumatic necrosis and penumbra—areas of
secondary neural injury which are crucial targets for therapeutic interventions. Segmenting …
secondary neural injury which are crucial targets for therapeutic interventions. Segmenting …
Diffusion MRI approaches for investigating microstructural complexity in a rat model of traumatic brain injury
K Chary, E Manninen, J Claessens… - Scientific Reports, 2023 - nature.com
Our study explores the potential of conventional and advanced diffusion MRI techniques
including diffusion tensor imaging (DTI), and single-shell 3-tissue constrained spherical …
including diffusion tensor imaging (DTI), and single-shell 3-tissue constrained spherical …
[HTML][HTML] Association of sub-acute changes in plasma amino acid levels with long-term brain pathologies in a rat model of moderate-severe traumatic brain injury
Introduction Traumatic brain injury (TBI) induces a cascade of cellular alterations that are
responsible for evolving secondary brain injuries. Changes in brain structure and function …
responsible for evolving secondary brain injuries. Changes in brain structure and function …
Alzheimer's-associated upregulation of mitochondria-associated ER membranes after traumatic brain injury
Traumatic brain injury (TBI) can lead to neurodegenerative diseases such as Alzheimer's
disease (AD) through mechanisms that remain incompletely characterized. Similar to AD …
disease (AD) through mechanisms that remain incompletely characterized. Similar to AD …