Location, location, location: Tissue resident memory T cells in mice and humans
The discovery of T cells resident in diverse tissues has altered our understanding of
adaptive immunity to encompass site-specific responses mediated by tissue-adapted …
adaptive immunity to encompass site-specific responses mediated by tissue-adapted …
BCG-induced cross-protection and development of trained immunity: implication for vaccine design
C Covián, A Fernández-Fierro, A Retamal-Díaz… - Frontiers in …, 2019 - frontiersin.org
The Bacillus Calmette-Guérin (BCG) is a live attenuated tuberculosis vaccine that has the
ability to induce non-specific cross-protection against pathogens that might be unrelated to …
ability to induce non-specific cross-protection against pathogens that might be unrelated to …
Generation and persistence of human tissue-resident memory T cells in lung transplantation
Tissue-resident memory T cells (TRM) maintain immunity in diverse sites as determined in
mouse models, whereas their establishment and role in human tissues have been difficult to …
mouse models, whereas their establishment and role in human tissues have been difficult to …
What have we learnt about BCG vaccination in the last 20 years?
HM Dockrell, SG Smith - Frontiers in immunology, 2017 - frontiersin.org
A number of new tuberculosis (TB) vaccines have been or are entering clinical trials, which
include genetically modified mycobacteria, mycobacterial antigens delivered by viral …
include genetically modified mycobacteria, mycobacterial antigens delivered by viral …
Pathophysiology of skin resident memory T cells
Y Tokura, P Phadungsaksawasdi, K Kurihara… - Frontiers in …, 2021 - frontiersin.org
Tissue resident memory T (TRM) cells reside in peripheral, non-lymphoid tissues such as
the skin, where they act as alarm-sensor cells or cytotoxic cells. Physiologically, skin TRM …
the skin, where they act as alarm-sensor cells or cytotoxic cells. Physiologically, skin TRM …
The BCG vaccine for COVID-19: first verdict and future directions
M Gonzalez-Perez, R Sanchez-Tarjuelo… - Frontiers in …, 2021 - frontiersin.org
Despite of the rapid development of the vaccines against the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), it will take several months to have enough doses …
syndrome coronavirus 2 (SARS-CoV-2), it will take several months to have enough doses …
Tissue‐resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance
T Gebhardt, U Palendira, DC Tscharke… - Immunological …, 2018 - Wiley Online Library
A large proportion of memory T cells disseminated throughout the body are non‐
recirculating cells whose maintenance and function is regulated by tissue‐specific …
recirculating cells whose maintenance and function is regulated by tissue‐specific …
Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung
T cell immunity is essential for the control of tuberculosis (TB), an important disease of the
lung, and is generally studied in humans using peripheral blood cells. Mounting evidence …
lung, and is generally studied in humans using peripheral blood cells. Mounting evidence …
Upper respiratory tract mucosal immunity for SARS-CoV-2 vaccines
R Fraser, A Orta-Resendiz, A Mazein… - Trends in molecular …, 2023 - cell.com
SARS-CoV-2 vaccination significantly reduces morbidity and mortality, but has less impact
on viral transmission rates, thus aiding viral evolution, and the longevity of vaccine-induced …
on viral transmission rates, thus aiding viral evolution, and the longevity of vaccine-induced …
Immune Responses to Bacillus Calmette–Guérin Vaccination: Why Do They Fail to Protect against Mycobacterium tuberculosis?
Mycobacterium tuberculosis (M. tb), the causative agent of tuberculosis (TB), is the current
leading cause of death due to a single infectious organism. Although curable, the broad …
leading cause of death due to a single infectious organism. Although curable, the broad …