TP53 is the most frequently mutated gene in human cancer. It encodes the tumor suppressor
protein p53, which suppresses tumorigenesis by acting as a critical transcription factor that …

MYC, a key member of the Myc-proto-oncogene family, is a universal transcription amplifier
that regulates almost every physiological process in a cell including cell cycle, proliferation …

Tumor suppressor p53 can transcriptionally activate downstream genes in response to
stress, and then regulate the cell cycle, DNA repair, metabolism, angiogenesis, apoptosis …

P53 is a master transcriptional regulator and effector of the DNA damage response (DDR)
that localizes to DNA damage sites, in part, via an interaction with PARP1. However, the …

Metastatic cutaneous squamous cell carcinoma (CSCC) is a highly morbid disease requiring
radical surgery and adjuvant therapy, which is associated with a poor prognosis. Yet …

The acquisition of resistance to traditional chemotherapy and the chemoresistant metastatic
relapse of minimal residual disease both play a key role in the treatment failure and poor …

Lower back pain (LBP) is a common degenerative musculoskeletal disease that imposes a
huge economic burden on both individuals and society. With the aggravation of social aging …

Ovarian cancer (OC) is the most lethal gynecologic cancer due primarily to its asymptomatic
nature and late stage at diagnosis. The development of non-invasive markers is an urgent …

TCR-engineered T cells have achieved great progress in solid tumor therapy, some of which
have been applicated in clinical trials. Deep knowledge about the current progress of TCR-T …

Simple Summary The RB and p53 pathways are two major tumor suppressive pathways.
Hence, in almost all cancers, both pathways are disabled. E2F transcription factor is under …