Abstract Aim From January 2013, the Parma Department of Mental Health developed a
specific protocol of care (the “Parma—Early Psychosis”[Pr‐EP] program) as a diffused …

Prediction of psychosis is already possible with an excellent prognostic performance based
on clinical assessments. Recent studies show that this accuracy can be further improved by …

Background: The aim of the European Brain Council project “The Value of Treatment” was to
provide evidence-based, cost-effective policy recommendations for a patient-centered and …

The clinical significance and the prognostic value of clinical high risk (CHR) for psychosis,
while substantially corroborated in adults, remains less firmly established in children and …

Background Dysregulation of immunity, such as levels of inflammatory factors, has been
regarded as a sign of schizophrenia. Changes in cytokine levels are not only described in …

For many years, the study of the psychotic phenotpe and approach to treatment of
schizophrenia has been focused on positive psychotic symptoms, although the functional …

Preclinical models propose that the onset of psychosis is associated with hippocampal
hyperactivity, thought to be driven by cortical GABAergic interneuron dysfunction and …

Objective A new 15-item version of the positive subscale of Community Assessment of
Psychic Experiences (CAPE-P15) has been recently proposed and used to measure …

Patients with an 'At risk mental state'(ARMS) for developing psychosis can be treated
successfully with CBT to postpone and prevent the transition to a first psychotic episode. A …

Current criteria identifying patients with ultra-high risk of psychosis (UHR) have low
specificity, and less than one-third of UHR cases experience transition to psychosis within 3 …