With a worldwide prevalence of 15%, chronic constipation is one of the most frequent
gastrointestinal diagnoses made in ambulatory medicine clinics, and is a common source …

Functional constipation (FC) is common, yet the etiology is not clear. Accumulating evidence
suggests an association between FC and abnormal gut microbiota. The relationship …

Dysfunction of the autonomic nervous system afflicts most patients with Parkinson disease
and other synucleinopathies such as dementia with Lewy bodies, multiple system atrophy …

Functional gastrointestinal (GI) disorders (FGIDs) result from central and peripheral
mechanisms, cause chronic remitting-relapsing symptoms, and are associated with …

Constipation, one of the most common prodromal non-motor symptoms of Parkinson's
disease (PD), usually occurs several years earlier than the onset of motor symptoms …

Constipation is a symptom that affects around 11–20% of the adult population yearly. Most
physicians consider infrequency of defecation as a hallmark of constipation. However, most …

The consumption of resistant dextrin improves constipation, while its fermentation and
degradation by the intestinal microbiota produce short-chain fatty acids (SCFA) and lactic …

Constipation, a condition characterized by heterogeneous symptoms, is common in Western
society. It is associated with reduced physical health, mental health, and social functioning …

The solubility of bisacodyl at 288.15–308.15 K was determined by solid-liquid equilibrium in
fourteen solvents commonly used in pharmaceutical production. The lowest solubility is in …

Introduction The increasing global prevalence of the symptoms of constipation adversely
affects the quality of life (QOL) of symptomatic patients. An acceptable universal definition of …