Ethnopharmacological relevance Panax ginseng CA Meyer (P. ginseng) is effective in the
prevention and treatment of myocardial ischemia-reperfusion (I/R) injury. The mechanism by …

Pulmonary fibrosis is a devastating lung disease with multifactorial etiology characterized by
alveolar injury, fibroblast proliferation and excessive deposition of extracellular matrix …

MasR is a critical element in the RAS accessory pathway that protects the heart against
myocardial infarction, ischemia-reperfusion injury, and pathological remodeling by …

The MrgD receptor agonist, alamandine (ALA) and Mas receptor agonist, AVE0991 have
recently been identified as protective components of the renin‐angiotensin system. We …

Weaning preeclamptic (PE) rats exhibit exaggerated endotoxic signs of hypotension and
cardiac autonomic neuropathy. Considering the role of renin-angiotensin system (RAS) in …

Alternative branches of the classical renin–angiotensin–aldosterone system (RAS)
represent an important cascade in which angiotensin 2 (AngII) undergoes cleavage via the …

Heart failure (HF) is one of the most critical health and economic burdens worldwide, and its
prevalence is continuously increasing. HF is a disease that occurs due to a pathological …

Background: Diabetes mellitus (DM) is a risk factor for cardiovascular diseases, specifically,
the ischemic heart diseases (IHD). The renin–angiotensin system (RAS) affects the heart …

Doxorubicin (DOX) is an anthracycline derivative used for treatment of malignancies;
however, its clinical use is limited by its cardiotoxicity. We investigated the effects of …

AVE 0991, a non-peptide analogue of Angiotensin-(1-7)[Ang-(1-7)], is orally active and
physiologically well tolerated. Several studies have demonstrated that AVE 0991 improves …