[HTML][HTML] Caspases and kinases in a death grip
M Kurokawa, S Kornbluth - Cell, 2009 - cell.com
The complex process of apoptosis is orchestrated by caspases, a family of cysteine
proteases with unique substrate specificities. Accumulating evidence suggests that cell …
proteases with unique substrate specificities. Accumulating evidence suggests that cell …
Matrix metalloproteinase-2 and myocardial oxidative stress injury: beyond the matrix
Abstract Matrix metalloproteinase (MMP)-2 belongs to a family of zinc-dependent proteases
which are best known for their ability to proteolyse extracellular matrix proteins throughout …
which are best known for their ability to proteolyse extracellular matrix proteins throughout …
The role of Cdc25A in the regulation of cell proliferation and apoptosis
Cell division cycle 25 A (Cdc25A), a dual-specificity protein phosphatase, is one of the most
crucial cell cycle regulators, which removes the inhibitory phosphorylation in cyclin …
crucial cell cycle regulators, which removes the inhibitory phosphorylation in cyclin …
The regulatory crosstalk between kinases and proteases in cancer
C López-Otín, T Hunter - Nature Reviews Cancer, 2010 - nature.com
Kinases and proteases are responsible for two fundamental regulatory mechanisms—
phosphorylation and proteolysis—that orchestrate the rhythms of life and death in all …
phosphorylation and proteolysis—that orchestrate the rhythms of life and death in all …
CRISPR-Cas knockout of miR21 reduces glioma growth
Non-coding RNAs, including microRNAs (miRNAs), support the progression of glioma. miR-
21 is a small, non-coding transcript involved in regulating gene expression in multiple …
21 is a small, non-coding transcript involved in regulating gene expression in multiple …
Caspase-6 and neurodegeneration
Caspases are cysteine-aspartic proteases that post-translationally modify their substrates
through cleavage at specific sites, which causes either substrate inactivation or a gain of …
through cleavage at specific sites, which causes either substrate inactivation or a gain of …
Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo
Caspase cleavage of huntingtin (htt) and nuclear htt accumulation represent early
neuropathological changes in brains of patients with Huntington's disease (HD). However …
neuropathological changes in brains of patients with Huntington's disease (HD). However …
Alterations in the nucleocytoplasmic transport in apoptosis: Caspases lead the way
GS Kopeina, EA Prokhorova, IN Lavrik… - Cell …, 2018 - Wiley Online Library
Apoptosis is a mode of regulated cell death that is indispensable for the morphogenesis,
development and homeostasis of multicellular organisms. Caspases are cysteine …
development and homeostasis of multicellular organisms. Caspases are cysteine …
Modulation of DNA damage response and induction of apoptosis mediates synergism between doxorubicin and a new imidazopyridine derivative in breast and lung …
DNA damage response machinery (DDR) is an attractive target of cancer therapy.
Modulation of DDR network may alter the response of cancer cells to DNA damaging …
Modulation of DDR network may alter the response of cancer cells to DNA damaging …
CDC25A targeting by miR-483-3p decreases CCND–CDK4/6 assembly and contributes to cell cycle arrest
Disruption of contact inhibition and serum afflux that occur after a tissue injury activate cell
cycle, which then stops when confluence is reached again. Although the events involved in …
cycle, which then stops when confluence is reached again. Although the events involved in …