Anti-cancer drugs targeting the DNA damage response (DDR) exploit genetic or functional
defects in this pathway through synthetic lethal mechanisms. For example, defects in …

Oral cladribine is a novel treatment for relapsing multiple sclerosis (MS). This appears to be
a semi-selective immune-reconstitution therapy that induces long-term therapy from short …

When bacterial cells come in contact, antagonism mediated by the delivery of toxins
frequently ensues. The potential for such encounters to have long-term beneficial …

Fluorinated nucleosides and oligonucleotides are of specific interest as probes for studying
nucleic acids interaction, structures, biological transformations, and its biomedical …

The deoxycytidine analogue cytarabine (ara‐C) remains the backbone treatment of acute
myeloid leukaemia (AML) as well as other haematological and lymphoid malignancies, but …

The exploitation of the DNA damage response and DNA repair proficiency of cancer cells is
an important anticancer strategy. The replication and repair of DNA are dependent upon the …

Treatment algorithms for metastatic breast cancer describe sequential treatment with
chemotherapy and, if appropriate, targeted therapy for as long as the patient receives …

Autophagy is a catabolic intracellular nutrient-scavenging pathway triggered by nutrient
deprivation and stress that captures and degrades intracellular proteins and organelles in …

Nucleosides play central roles in all facets of life, from metabolism to cellular signaling.
Because of their physiochemical properties, nucleosides are lipid bilayer impermeable and …

Nucleobase and nucleoside analogs (NNA) are widely used as anti-viral and anti-cancer
agents, and NNA phosphorylation is essential for the activity of this class of drugs. Recently …