Increasing evidence highlights the role of lipid metabolism in tumorigenesis and tumor
progression. Targeting the processes of lipid metabolism, including lipogenesis, lipid …

Bone remodeling is a continuous and dynamic process of bone formation and resorption to
maintain its integrity and homeostasis. Bone marrow is a source of various cell lineages …

Background Ferroptosis is an iron-related form of programmed cell death. Accumulating
evidence has identified the pathogenic role of ferroptosis in multiple orthopedic disorders …

Chemokines are recognized as the major contributor to various tumorigenesis, tumor
heterogeneity, and failures of current cancer therapies. The tumor microenvironment (TME) …

Cancer cachexia is a complex multifaceted syndrome involving functional impairment and
changes in body composition that cannot be reversed by nutritional support. Cancer …

Growth differentiation factor 15 (GDF15) has been reported to play an important role in
cancer and is secreted and involved in the progression of various cancers, including ovarian …

Prostate cancer (PCa) is an increasingly prevalent health problem in the developed world.
Effective treatment options exist for localized PCa, but metastatic PCa has fewer treatment …

Abstract Growth differentiation factor 15 (GDF15), a member of the transforming growth
factor‑β family, is a stress‑induced cytokine. Under normal circumstances, the expression of …

Castration-resistance of prostate cancer is one of the most challenging clinical problems. In
the present study, we have performed proteomics and glycomics using LNCaP model …

Background Patients with chronic kidney disease (CKD) typically exhibit circulating growth
differentiation factor-15 (GDF-15) at high levels. This meta-analysis aimed to evaluate the …