A number of industrial chemicals and therapeutic agents cause liver tumors in rats and mice
by activating the nuclear receptor peroxisome proliferator-activated receptor α (PPARα). The …

Phthalates are a class of compounds that have been extensively used as plasticizers in
different applications. Several phthalates have been recognized as substances of very high …

The plasticizer di (2-ethylhexyl) phthalate (DEHP) is suspected to induce antiandrogenic
effects in men via its metabolite mono (2-ethylhexyl) phthalate (MEHP). However, there is …

Advancements in measurement and modeling capabilities are providing unprecedented
access to estimates of chemical exposure and bioactivity. With this influx of new data, there …

A higher body mass index (BMI) has been positively associated with the rate of excretion of
di-2-ethylhexyl phthalate (DEHP) metabolites in urine in data from the National Health and …

Pregnant Sprague-Dawley rats received 50, 250, and 500mg/kg/day diisononyl phthalate
(DiNP) from GD 12 to 19 via corn oil gavage to study the dose response for effects on fetal …

Octamethylcyclotetrasiloxane (D 4) is a low-molecular-weight volatile cyclic siloxane,
primarily used as an intermediate in the production of some widely-used industrial and …

Biomarkers of exposure can be measured at lower and lower levels due to advances in
analytical chemistry. Using these sensitive methods, some epidemiology studies report …

Phthalates are a family of industrial and consumer product chemicals, among which diethyl
phthalate (DEP) has been widely used. DEP is metabolized into the active metabolite …

Given the opportunities provided by internal dosimetry modelling in the interpretation of
human biomonitoring (HBM) data, the assessment of the links between exposure to …