While it is known that lipids play an essential role in regulating membrane protein structure
and function, it remains challenging to identify specific protein–lipid interactions. Here, we …

The TREK-1 channel belongs to the TREK subfamily of two-pore domains channels that are
activated by stretch and polyunsaturated fatty acids and inactivated by Protein Kinase A …

The two-pore domain K2P subunits form background (leak) potassium channels, which are
characterized by constitutive, although not necessarily constant activity, at all membrane …

The excitatory and inhibitory effects of single and brief infrared (IR) light pulses (2 µm) with
millisecond durations and various power levels are investigated with a custom-built fiber …

Synaptic plasticity is one of the putative mechanisms involved in the maturation of the
prefrontal cortex (PFC) during postnatal development. Early life stress (ELS) affects the …

TREK-1 is a mechanosensitive channel activated by polyunsaturated fatty acids (PUFAs). Its
activation is supposed to be linked to changes in membrane tension following PUFAs …

TREK-1 channels are expressed in small nociceptive dorsal root ganglion (DRG) neurons
where they participate in acute inflammatory and neuropathic pain. However, the role of …

Major depressive disorder (MDD) refers to a widespread psychiatric disorder. Astrocytes
play a pivotal role in regulating inflammation which is a well-acknowledged key component …

Astrocytes, the most abundant cell type in the brain, are non-excitable cells and play critical
roles in brain function. Mature astrocytes typically exhibit a linear current–voltage …

Intrauterine infection during pregnancy can enhance uterine contractions. A two-pore K+
channel TREK1 is crucial for maintaining uterine quiescence and reducing contractility, with …