Introduction: Driving hours and rest breaks are closely related to driver fatigue, which is a
major contributor to truck crashes. This study investigates the effects of driving hours and …

Background and Purpose—Combined effects of socioeconomic position and well-
established risk factors on stroke incidence have not been formally investigated. Methods …

Motivation Estimating the effects of interventions on patient outcome is one of the key
aspects of personalized medicine. Their inference is often challenged by the fact that the …

Instrumental variable (IV) analysis is an increasingly popular tool for inferring the effect of an
exposure on an outcome, as witnessed by the growing number of IV applications in …

Survival data analysis is a very broad field of statistics, encompassing a large variety of
methods used in a wide range of applications, and in particular in medical research. During …

Background: Inuits of the Arctic experience very high rates of chronic suppurative otitis
media (CSOM), yet world-wide, very little is known about the epidemiology of CSOM. The …

Background: Alcohol-related mortality is more pronounced in lower than in higher
socioeconomic groups in Western countries. Part of the explanation is differences in drinking …

A frequent occurrence in medical research is that a patient is subject to different causes of
failure, where each cause is known as a competing risk. The cumulative incidence curve is a …

This article introduces the pammtools package, which facilitates data transformation,
estimation and interpretation of Piece-wise exponential Additive Mixed Models. A special …

Survival and event history analysis have developed into one of the major areas of
biostatistics, with important applications in other fields as well, including reliability theory …