Gonadotropin-releasing hormone (GnRH) secretion has two modes of release in
mammalian species; the surge mode and the pulse mode. The surge mode, which is …

Loss-of-function mutations in the genes encoding either neurokinin B (NKB) or its receptor,
NK3 (NK3R), result in hypogonadotropic hypogonadism, characterized by an absence of …

The timely secretion of gonadal sex steroids is essential for the initiation of puberty, the
postpubertal maintenance of secondary sexual characteristics and the normal perinatal …

Human genetics indicate that kisspeptin and neurokinin B (NKB) signaling are necessary for
generating pulsatile LH release and therefore for initiation of puberty and maintaining …

Context: Missense loss-of-function mutations in TAC3 and TACR3, the genes encoding
neurokinin B and its receptor NK3R, respectively, were recently discovered in kindreds with …

In rodents, previous findings indicate critical involvement of the medial preoptic area (MPOA)
in the neural control of maternal behavior. However, the specification of the particular MPOA …

Pulsatile gonadotropin-releasing hormone (GnRH) is crucial to normal reproductive function
and abnormalities in pulse frequency give rise to reproductive dysfunction. Kisspeptin and …

Context: The neurokinin B (NKB) receptor, encoded by TACR3, is widely expressed within
the central nervous system, including hypothalamic nuclei involved in regulating GnRH …

Reproductive hormones affect all stages of life from gamete production, fertilization, fetal
development and parturition, neonatal development and puberty through to adulthood and …

Human genetics have revealed that kisspeptin signaling and neurokinin B (NKB) signaling
are both required for robust pulsatile gonadotropin-releasing hormone (GnRH) release, and …