As a complex multicellular structure of the vascular system at the central nervous system
(CNS), the blood-brain barrier (BBB) separates the CNS from the system circulation and …

Dysregulated host response to infection, which cause life‐threatening organ dysfunction,
was defined as sepsis. Sepsis can cause acute and long‐term brain dysfunction, namely …

Background Cognitive deficits are common in patients with sepsis. Previous studies in
sepsis-associated encephalopathy (SAE) implicated the CXC chemokine receptor type …

The pathology of sepsis‐associated encephalopathy (SAE) is related to astrocyte‐
inflammation associated with aquaporin‐4 (AQP4). The aim here is to investigate the effects …

Brucella is a typical facultative intracellular bacterium that can cause zoonotic infections. For
Brucella, it is difficult to eliminate with current medical treatment. Therefore, a multi-epitope …

Objective: Sepsis-associated encephalopathy (SAE) is a severe and common complication
of sepsis and can induce cognitive dysfunction and apoptosis of neurons and …

ABSTRACT Background We compared Systemic Inflammatory Response Syndrome (SIRS),
Sequential Organ Failure Assessment (SOFA), Quick Sepsis-related Organ Failure …

Sexual dimorphisms exist in multiple domains, from learning and memory to neurocognitive
disease, and even in the immune system. Male sex has been associated with increased …

Pain is a common clinical condition. However, the mechanisms underlying pain are not yet
fully understood. It is known that the neuroimmune system plays a critical role in the …

Anesthesia-induced neurotoxicity is a set of unfavorable adverse effects on central or
peripheral nervous systems associated with administration of anesthesia. Several animal …