Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer
activities, including anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects …

Berberine, an isoquinoline alkaloid isolated from the Chinese herb Coptis chinensis and
other Berberis plants, has a wide range of pharmacological properties. Berberine can be …

Alkaloids are used in traditional medicine for the treatment of many diseases. These
compounds are synthesized in plants as secondary metabolites and have multiple effects on …

Purpose Growing solid tumors mostly outstrip blood supply and become hypoxic (low
oxygen supply). To survive under this pathological milieu, tumors overexpress a potent …

Breast cancer has an extremely high incidence in women, and its morbidity and mortality
rank first among female tumors. With the increasing development of medicine today, the …

Ethnopharmacological relevance The antineoplastic property of Coptidis Rhizoma and
berberine was correlated with its traditional use of clearing internal fire, removing damp-heat …

Cancer is a serious disease with an increasing number of reported cases and high mortality
worldwide. Gastrointestinal cancer defines a group of cancers in the digestive system, eg …

Esophageal squamous cell carcinoma (ESCC) is the sixth most common cause of cancer-
related mortality worldwide, with more than half of them occurred in China. Radiotherapy …

Background The poor bioavailability of Berberine (BBR) and Betulinic acid (BA) limits the
development of these promising anticancer agents for clinical use. In the current study, BBR …

Breast cancer is the most common malignancy in women. Although personalized or
targeting molecular cancer therapy is more popular up to now, the cytotoxicity chemotherapy …