A novel deletion of the MEN1 gene in a large family of multiple endocrine neoplasia type 1 (MEN1) with aggressive phenotype

H Raef, M Zou, EY Baitei, RA Al‐Rijjal… - Clinical …, 2011 - Wiley Online Library
Context The MEN1 syndrome is associated with parathyroid, pancreatic and pituitary
tumours and is caused by mutations in the MEN1 gene. In general, there is no genotype …

Laparoscopic surgery in patients with sporadic and multiple insulinomas associated with multiple endocrine neoplasia type 1

L Fernández-Cruz, I Martínez, G Cesar-Borges… - Journal of …, 2005 - Springer
There have recently been reports of a limited number of laparoscopic procedures in patients
with clinically manifest hyperinsulinism. However, the precise role of laparoscopy remains …

Primary hyperparathyroidism in patients with multiple endocrine neoplasia type 1: Impact of genotype and surgical approach on long-term postoperative outcomes

OA Shariq, VB Abrantes, LY Lu, PJ Tebben, TM Foster… - Surgery, 2024 - Elsevier
Background Protein-truncating germline pathogenic variants in the N-and C-terminal exons
(2, 9, and 10) of the MEN1 gene may be associated with aggressive pancreatic …

[PDF][PDF] Multiple Endocrine Neoplasia Type 1 Syndrome Pancreatic Neuroendocrine Tumor Genotype/Phenotype: Is There Any Advance on Predicting or Preventing?

B Ramamoorthy, N Nilubol - Surgical Oncology Clinics of North America, 2023 - Elsevier
Multiple endocrine neoplasia type 1 syndrome (MEN1) is a disease caused by mutations in
the MEN1 tumor suppressor gene leading to hyperparathyroidism, pituitary adenomas, and …

[HTML][HTML] The current strategy for managing pancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1

Y Niina, N Fujimori, T Nakamura, H Igarashi, T Oono… - Gut and liver, 2012 - ncbi.nlm.nih.gov
Multiple endocrine neoplasia type 1 (MEN1) is an inherited autosomal dominant disease
presenting with pancreatic neuroendocrine tumors (pNETs), parathyroid tumors, or pituitary …

Multiple endocrine neoplasia type 1: fresh perspective on clinical features and penetrance

JM Glascock, SE Carty - Surgical oncology, 2002 - Elsevier
Multiple endocrine neoplasia type 1 (MEN-1) is an interesting genetic syndrome of
polyendocrinopathies. Clinical knowledge about MEN-1 is essential as it appears to be …

Prevalence of multiple endocrine neoplasia type 1 in young patients with apparently sporadic primary hyperparathyroidism or pancreaticoduodenal endocrine …

P Langer, A Wild, A Hall, I Celik… - Journal of British …, 2003 - academic.oup.com
Background The appropriate treatment for a sporadic endocrine tumour may be different
from those that present as part of the multiple endocrine neoplasia type 1 (MEN1) syndrome …

Pancreatoduodenal surgery in patients with multiple endocrine neoplasia type 1: operative outcomes, long-term function, and quality of life

YN You, GB Thompson, WF Young Jr, D Larson… - Surgery, 2007 - Elsevier
BACKGROUND: Pancreatoduodenal (PD) neoplasms represent the principal disease-
specific lethality in multiple endocrine neoplasia type 1 (MEN1). Potential oncologic benefits …

Completion pancreatectomy and duodenectomy for recurrent MEN-1 pancreaticoduodenal endocrine neoplasms

PG Gauger, GM Doherty, JT Broome, BS Miller… - Surgery, 2009 - Elsevier
BACKGROUND: The purpose of this study is to describe outcomes of MEN-1 patients with
recurrence requiring completion pancreatectomy and duodenectomy after initial treatment of …

Conservative management and parenchyma-sparing resections of pancreatic neuroendocrine tumors: literature review

C Mauriello, S Napolitano, C Gambardella… - … Journal of Surgery, 2015 - journals.lww.com
Background: Pancreatic neuroendocrine tumors (pNETs) are uncommon entities. pNETs are
often small, slow growing, clinically silent neoplasms. However, they have an almost …