Ectopic discharge in axotomized dorsal root ganglion neurons is a key driver of neuropathic
pain. However, the bulk of this activity is generated and carried centrally in large diameter …

Pain normally subserves a vital role in the survival of the organism, prompting the avoidance
of situations associated with tissue damage. However, the sensation of pain can become …

Chemokines and chemokine receptors are widely expressed by cells of the immune and
nervous systems. This review focuses on our current knowledge concerning the role of …

C-nociceptors do not normally fire action potentials unless challenged by adequate noxious
stimuli. However, in pathological states nociceptors may become hyperexcitable and may …

Trigeminal nerve injury is one of the causes of chronic orofacial pain. Patients suffering from
this condition have a significantly reduced quality of life. The currently available …

Paclitaxel-induced peripheral neuropathy (PN) can be a significant problem for patients
receiving chemotherapeutic regimens for the treatment of breast, ovarian, and lung cancer …

Marine phycotoxins are a multiplicity of bioactive compounds which are produced by
microalgae and bioaccumulate in the marine food web. Phycotoxins affect the ecosystem …

Background: The mechanism of chemotherapy-induced peripheral neuropathy after
paclitaxel treatment is not well understood. Given the poor penetration of paclitaxel into …

Tetrodotoxin (TTX) is a potent neurotoxin that blocks voltage-gated sodium channels
(VGSCs). VGSCs play a critical role in neuronal function under both physiological and …

Mechanisms underlying chronic pain that develops after spinal cord injury (SCI) are
incompletely understood. Most research on SCI pain mechanisms has focused on neuronal …