The heart is a very complex conglomeration of organized interactions between various
different cell types that all aid in facilitating myocardial function through contractility, sufficient …

Myocardial infarction (cardiac tissue death) is among the most prevalent causes of death
among the cardiac patients due to the inability of self-repair in cardiac tissues. Myocardial …

Bioengineering of a functional cardiac tissue composed of primary cardiomyocytes has great
potential for myocardial regeneration and in vitro tissue modeling. However, its applications …

In mammals, enlargement of the heart during embryonic development is primarily
dependent on the increase in cardiomyocyte numbers. Shortly after birth, however …

Abstract Background Extracellular vesicles (EVs) and exosomes are nano-sized, membrane-
bound vesicles shed by most eukaryotic cells studied to date. EVs play key signaling roles in …

Background In humans, myocardial infarction is characterized by irreversible loss of heart
tissue, which becomes replaced with a fibrous scar. By contrast, teleost fish and urodele …

The human heart cannot regenerate after an injury. Lost cardiomyocytes are replaced by
scar tissue resulting in reduced cardiac function causing high morbidity and mortality. One …

Aging is a risk factor for heart failure, which is a leading cause of death world-wide. Elderly
patients are more likely than young patients to experience a myocardial infarction (MI) and …

MicroRNA (miRNA) directs post-transcriptional regulation of a network of genes by targeting
mRNA. Although relatively recent in development, many miRNAs direct differentiation of …

Unlike its mammalian counterpart, the adult zebrafish heart is able to fully regenerate after
severe injury. One of the most important events during the regeneration process is …