Antibody‐based cancer therapy, one of the most significant therapeutic strategies, has
achieved considerable success and progress over the past decades. Nevertheless …

In the last few years, there have been significant advances in migraine management and
prevention. Lasmiditan, ubrogepant, rimegepant and monoclonal antibodies (erenumab …

The optimization of therapeutic antibodies is time-intensive and resource-demanding,
largely because of the low-throughput screening of full-length antibodies (approximately 1× …

Background Concizumab is an anti–tissue factor pathway inhibitor monoclonal antibody
designed to achieve hemostasis in all hemophilia types, with subcutaneous administration …

Importance Administration of atezolizumab could be immunogenic and induce undesirable
antidrug antibody (ADA) responses. This may interfere with atezolizumab-mediated actions …

Botulinum neurotoxins (BoNTs) are proteins produced by bacteria of the Clostridium family.
Upon oral ingestion, BoNT causes the neuroparalytic syndrome botulism. There are seven …

Drug discovery and development has experienced an incredible paradigm shift in the past
two decades. What once was considered a predominant R&D landscape of small molecules …

Background Antidrug antibodies (ADAs) may worsen the efficacy and safety of biologics.
However, little is known about the incidence of ADAs associated with the 6 biologics …

The last two decades have witnessed a continuously increasing number of
biomacromolecules approved for the treatment of ocular diseases. The eye possesses …

Rheumatoid arthritis (RA) is an autoimmune disorder characterized by inflammation and
bone erosion. The exact mechanism of RA is still unknown, but various immune cytokines …