The physiological balance between excitation and inhibition in the brain is significantly
affected in Alzheimer's disease (AD). Several neuroactive compounds and their signaling …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by severe
cognitive deficits and pathologically by amyloid plaques, neuronal loss, and neurofibrillary …

Neuroplasticity, which is the dynamic structural and functional reorganization of central
nervous system connectivity due to environmental and internal demands, is recognized as a …

Objective To propose a new hypothesis that GABAergic dysfunction in excitatory and
inhibitory (E/I) imbalance drives the pathogenesis of Alzheimer's disease (AD). Background …

γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the vertebrate brain.
In the past, there has been a major research drive focused on the dysfunction of the …

Abstract γ-aminobutyric acid type B (GABA B) receptors are broadly expressed in the
nervous system and play an important role in neuronal excitability. GABA B receptors are G …

Introduction Loss of synapses best correlates to cognitive deficits in Alzheimer's disease
(AD) in which oligomeric neurotoxic species of amyloid-β appears to contribute synaptic …

Although it is evident from the literature that altered GABA B receptor function does affect
behavior, these results often do not correspond well. These differences could be due to the …

Background: Microarray technologies have identified imbalances in the expression of
specific genes and biological pathways in Alzheimer's disease (AD) brains. However, there …

The central nervous system, once thought to be a site of immunological privilege, has since
been found to harbour immunocompetent cells and to communicate with the peripheral …