Bacterial protein toxins that modify host regulatory GTPases
K Aktories - Nature Reviews Microbiology, 2011 - nature.com
Many bacterial pathogens produce protein toxins to outmanoeuvre the immune system of
the host. Some of these proteins target regulatory GTPases such as those belonging to the …
the host. Some of these proteins target regulatory GTPases such as those belonging to the …
Novel bacterial ADP-ribosylating toxins: structure and function
NC Simon, K Aktories, JT Barbieri - Nature Reviews Microbiology, 2014 - nature.com
Bacterial ADP-ribosyltransferase toxins (bARTTs) transfer ADP-ribose to eukaryotic proteins
to promote bacterial pathogenesis. In this Review, we use prototype bARTTs, such as …
to promote bacterial pathogenesis. In this Review, we use prototype bARTTs, such as …
[HTML][HTML] Fascia is able to actively contract and may thereby influence musculoskeletal dynamics: a histochemical and mechanographic investigation
Fascial tissues form a ubiquitous network throughout the whole body, which is usually
regarded as a passive contributor to biomechanical behavior. We aimed to answer the …
regarded as a passive contributor to biomechanical behavior. We aimed to answer the …
[HTML][HTML] Historical and current perspectives on Clostridium botulinum diversity
TJ Smith, KK Hill, BH Raphael - Research in microbiology, 2015 - Elsevier
For nearly one hundred years, researchers have attempted to categorize botulinum
neurotoxin-producing clostridia and the toxins that they produce according to biochemical …
neurotoxin-producing clostridia and the toxins that they produce according to biochemical …
Spatiotemporally controlled release of rho‐inhibiting C3 toxin from a protein–DNA hybrid hydrogel for targeted inhibition of osteoclast formation and activity
J Gačanin, A Kovtun, S Fischer… - Advanced …, 2017 - Wiley Online Library
In osteoporosis, bone structure can be improved by the introduction of therapeutic molecules
inhibiting bone resorption by osteoclasts. Here, biocompatible hydrogels represent an …
inhibiting bone resorption by osteoclasts. Here, biocompatible hydrogels represent an …
[HTML][HTML] Hsp70 facilitates trans-membrane transport of bacterial ADP-ribosylating toxins into the cytosol of mammalian cells
K Ernst, J Schmid, M Beck, M Hägele, M Hohwieler… - Scientific reports, 2017 - nature.com
Binary enterotoxins Clostridium (C.) botulinum C2 toxin, C. perfringens iota toxin and C.
difficile toxin CDT are composed of a transport (B) and a separate non-linked enzyme (A) …
difficile toxin CDT are composed of a transport (B) and a separate non-linked enzyme (A) …
Bacterial factors exploit eukaryotic Rho GTPase signaling cascades to promote invasion and proliferation within their host
MR Popoff - Small GTPases, 2014 - Taylor & Francis
Actin cytoskeleton is a main target of many bacterial pathogens. Among the multiple
regulation steps of the actin cytoskeleton, bacterial factors interact preferentially with …
regulation steps of the actin cytoskeleton, bacterial factors interact preferentially with …
Cyclophilin-facilitated membrane translocation as pharmacological target to prevent intoxication of mammalian cells by binary clostridial actin ADP-ribosylated toxins
K Ernst, S Langer, E Kaiser, C Osseforth… - Journal of molecular …, 2015 - Elsevier
Clostridium botulinum C2 toxin, Clostridium perfringens iota toxin and Clostridium difficile
CDT belong to the family of binary actin ADP-ribosylating toxins and are composed of a …
CDT belong to the family of binary actin ADP-ribosylating toxins and are composed of a …
[HTML][HTML] C3larvin toxin, an ADP-ribosyltransferase from Paenibacillus larvae
D Krska, R Ravulapalli, RJ Fieldhouse, MR Lugo… - Journal of Biological …, 2015 - ASBMB
C3larvin toxin was identified by a bioinformatic strategy as a putative mono-ADP-
ribosyltransferase and a possible virulence factor from Paenibacillus larvae, which is the …
ribosyltransferase and a possible virulence factor from Paenibacillus larvae, which is the …
The chaperone Hsp90 and PPIases of the cyclophilin and FKBP families facilitate membrane translocation of Photorhabdus luminescens ADP‐ribosyltransferases
AE Lang, K Ernst, H Lee, P Papatheodorou… - Cellular …, 2014 - Wiley Online Library
TccC 3 and TccC 5 from P hotorhabdus luminescens are ADP‐ribosyltransferases, which
modify actin and R ho GTP ases, respectively, thereby inducing polymerization and …
modify actin and R ho GTP ases, respectively, thereby inducing polymerization and …