Background Although hematologic malignancies and some solid tumors such as germ cell
tumors and pediatric malignancies can be cured by cytotoxic treatment, the most prevalent …

Extensive studies indicate that both p53 and multidrug transporters play important roles in
chemoresistance. Since the initial reports a decade ago demonstrating a transcriptional …

Wild-type p53 is frequently mutated in late-stage ovarian cancer and has been proposed as
a determinant of cisplatin chemosensitivity. We have therefore established a human ovarian …

Methionine aminopeptidase-2 (MetAP2) is the molecular target of the angiogenesis
inhibitors, fumagillin and ovalacin. Fumagillin can also inhibit cancer cell proliferation …

The impact of p53 status on cellular sensitivity to antifolate drugs has been examined in
seven human cell lines (A549, MCF7, T-47D, CCRF-CEM, COR-L23, A2780, and HCT-116) …

Background The involvement of protein kinase CK2 in sustaining cancer cell survival could
have implications also in the resistance to conventional and unconventional therapies …

Terfenadine (TF), a highly potent histamine H1 receptor antagonist, has been shown to exert
no significant central nervous system side effects in clinically effective doses. In this study …

Acute myeloid leukemia (AML) is an aggressive malignancy that leads to marrow failure and
death. There is a desperate need for new therapies. The novel fluoropyrimidine, FdUMP …

The identification of protein biomarkers for acute myeloid leukemia (AML) that could find
applications in AML diagnosis and prognosis, treatment and the selection for bone marrow …

Background p53 plays a key role in the apoptotic event induced by chemotherapeutic
agents. Mutation of p53 gene has been observed in various spontaneous tumors in humans …