Importance Oncolytic viruses (OVs) are emerging as important agents in cancer treatment.
Oncolytic viruses offer the attractive therapeutic combination of tumor-specific cell lysis …

Oncolytic virotherapy is an emerging treatment modality that uses replication-competent
viruses to destroy cancers. Recent advances include preclinical proof of feasibility for a …

Oncolytic viruses (OV) selectively replicate and kill cancer cells and spread within the tumor,
while not harming normal tissue. In addition to this direct oncolytic activity, OVs are also very …

Vaccine and laboratory adapted strains of measles virus can use CD46 as a receptor to
infect many human cell lines. However, wild type isolates of measles virus cannot use CD46 …

Bispecific T cell engagers (BiTEs) are an innovative class of immunotherapeutics that
redirect T cells to tumor surface antigens. While efficacious against certain hematological …

This review discusses current clinical advancements in oncolytic viral therapy, with a focus
on the viral platforms approved for clinical use and highlights the benefits each platform …

Most viruses are naturally immunogenic and can be engineered to express tumor antigen
transgenes. Moreover, many types of recombinant viruses have been shown to infect …

Single-stranded RNA viruses such as alphaviruses, flaviviruses, measles viruses and
rhabdoviruses are characterized by their capacity of highly efficient self-amplification of RNA …

Attenuated Edmonston lineage measles virus (MV-Edm) vaccine strains can preferentially
infect and lyse a wide variety of cancer cells. Oncolytic MV-Edm derivatives are genetically …

Human adenoviruses (Ads) have long been studied in the basic virology field and are
exploited as vectors for gene therapy, vaccination, and oncolytic therapy. Ads are usually …