Emerging concepts in the science of vaccine adjuvants
B Pulendran, P S. Arunachalam… - Nature Reviews Drug …, 2021 - nature.com
Adjuvants are vaccine components that enhance the magnitude, breadth and durability of
the immune response. Following its introduction in the 1920s, alum remained the only …
the immune response. Following its introduction in the 1920s, alum remained the only …
Diversity and dynamism of IgA− microbiota interactions
IgA mediates microbial homeostasis at the intestinal mucosa. Within the gut, IgA acts in a
context-dependent manner to both prevent and promote bacterial colonization and to …
context-dependent manner to both prevent and promote bacterial colonization and to …
[HTML][HTML] Gut microbiota composition is associated with SARS-CoV-2 vaccine immunogenicity and adverse events
Objective The gut microbiota plays a key role in modulating host immune response. We
conducted a prospective, observational study to examine gut microbiota composition in …
conducted a prospective, observational study to examine gut microbiota composition in …
Utilization of the microbiome in personalized medicine
Inter-individual human variability, driven by various genetic and environmental factors,
complicates the ability to develop effective population-based early disease detection …
complicates the ability to develop effective population-based early disease detection …
Metabolic programs tailor T cell immunity in viral infection, cancer, and aging
SH Møller, PC Hsueh, YR Yu, L Zhang, PC Ho - Cell metabolism, 2022 - cell.com
Productive T cell responses to infection and cancer rely on coordinated metabolic
reprogramming and epigenetic remodeling among the immune cells. In particular, T cell …
reprogramming and epigenetic remodeling among the immune cells. In particular, T cell …
[HTML][HTML] Gut-on-a-chip: Mimicking and monitoring the human intestine
Over the last few years, the intestine has been extensively studied using in vitro microfluidic
systems, commonly known as gut-on-a-chip (GOC) devices. This interest has been due not …
systems, commonly known as gut-on-a-chip (GOC) devices. This interest has been due not …
Microbiota regulation of viral infections through interferon signaling
NI Wirusanti, MT Baldridge, VC Harris - Trends in microbiology, 2022 - cell.com
The interferon (IFN) response is the major early innate immune response against invading
viral pathogens and is even capable of mediating sterilizing antiviral immunity without the …
viral pathogens and is even capable of mediating sterilizing antiviral immunity without the …
Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth
The dynamics of immunity to infection in infants remain obscure. Here, we used a multi-
omics approach to perform a longitudinal analysis of immunity to severe acute respiratory …
omics approach to perform a longitudinal analysis of immunity to severe acute respiratory …
Gut microbiome immaturity and childhood acute lymphoblastic leukaemia
I Peppas, AM Ford, CL Furness, MF Greaves - Nature Reviews Cancer, 2023 - nature.com
Acute lymphoblastic leukaemia (ALL) is the most common cancer of childhood. Here, we
map emerging evidence suggesting that children with ALL at the time of diagnosis may have …
map emerging evidence suggesting that children with ALL at the time of diagnosis may have …
Fighting the SARS-CoV-2 pandemic requires a global approach to understanding the heterogeneity of vaccine responses
Host genetic and environmental factors including age, biological sex, diet, geographical
location, microbiome composition and metabolites converge to influence innate and …
location, microbiome composition and metabolites converge to influence innate and …