miRNAs as therapeutic targets in inflammatory disease

Q Lu, R Wu, M Zhao, A Garcia-Gomez… - Trends in pharmacological …, 2019 - cell.com
In the past decade, we have witnessed considerable developments in understanding the
roles and functions of miRNAs. In parallel, the identification of alterations in miRNA …

The role of microRNA in psoriasis: A review

X Jiang, R Shi, R Ma, X Tang, Y Gong… - Experimental …, 2023 - Wiley Online Library
Psoriasis is a chronic immune‐mediated inflammatory skin disease that involves a complex
interplay between infiltrated immune cells and keratinocytes. Great progress has been made …

[HTML][HTML] Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype

L Terlecki-Zaniewicz, I Lämmermann, J Latreille… - Aging (Albany …, 2018 - ncbi.nlm.nih.gov
Loss of functionality during aging of cells and organisms is caused and accompanied by
altered cell-to-cell communication and signalling. One factor thereby is the chronic …

BMSC-derived exosomes carrying microRNA-122-5p promote proliferation of osteoblasts in osteonecrosis of the femoral head

W Liao, YU Ning, HJ Xu, WZ Zou, J Hu, XZ Liu… - Clinical …, 2019 - portlandpress.com
Mesenchymal stem cells (MSCs) with multipotential differentiation capacity can differentiate
into bone cells under specific conditions and can be used to treat osteonecrosis (ON) of the …

[HTML][HTML] Adipose mesenchymal stromal cell-derived exosomes carrying MiR-122-5p antagonize the inhibitory effect of dihydrotestosterone on hair follicles by targeting …

Y Liang, X Tang, X Zhang, C Cao, M Yu… - International Journal of …, 2023 - mdpi.com
Androgenic alopecia (AGA) is the most common type of hair loss, where local high
concentrations of dihydrotestosterone (DHT) in the scalp cause progressive shrinkage of the …

[HTML][HTML] MicroRNAs in several cutaneous autoimmune diseases: Psoriasis, cutaneous lupus erythematosus and atopic dermatitis

S Domingo, C Solé, T Moliné, B Ferrer… - Cells, 2020 - mdpi.com
MicroRNAs (miRNAs) are endogenous small non-coding RNA molecules that regulate the
gene expression at a post-transcriptional level and participate in maintaining the correct cell …

Insights into interplay of immunopathophysiological events and molecular mechanistic cascades in psoriasis and its associated comorbidities

AK Srivastava, TC Yadav, HK Khera, P Mishra… - Journal of …, 2021 - Elsevier
Psoriasis is an inflammatory skin disease with complex pathogenesis and multiple
etiological factors. Besides the essential role of autoreactive T cells and constellation of …

[HTML][HTML] miRNA-122-5p stimulates the proliferation and DNA synthesis and inhibits the early apoptosis of human spermatogonial stem cells by targeting CBL and …

F Zhou, W Chen, Y Cui, B Liu, Q Yuan, Z Li… - Aging (Albany NY …, 2020 - ncbi.nlm.nih.gov
Epigenetic regulators of human spermatogonia stem cells (SSCs) remain largely unknown.
We found that miRNA-122-5p was upregulated in human spermatogonia from obstructive …

The lncRNA H19/miR‐766‐3p/S1PR3 Axis Contributes to the Hyperproliferation of Keratinocytes and Skin Inflammation in Psoriasis via the AKT/mTOR Pathway

Y He, X Yin, J Yan, X Li, Q Sun - Mediators of Inflammation, 2021 - Wiley Online Library
Background. The pathogenesis of long noncoding RNAs (lncRNAs) and microRNAs
(miRNAs) are well studied in psoriasis. However, little is known about how specific lncRNAs …

Downregulation of miR‐145‐5p contributes to hyperproliferation of keratinocytes and skin inflammation in psoriasis

JJ Yan, M Qiao, RH Li, XT Zhao… - British Journal of …, 2019 - academic.oup.com
Background The extensive involvement of microRNAs (miRNAs) in the pathogenesis of
psoriasis is well documented. However, little is known about the contribution of specific …