Despite the best available medical treatments, many patients continue to be disabled by
neurologic and psychiatric disorders, resulting in a large unmet need. Advances in imaging …

Corticostriatal circuits through the orbitofrontal cortex (OFC) play key roles in complex
human behaviors such as evaluation, affect regulation and reward-based decision-making …

Background Subcallosal cingulate white matter (SCC) deep brain stimulation (DBS) is an
evolving investigational treatment for depression. Mechanisms of action are hypothesized to …

BACKGROUND: Treatment-resistant major depressive disorder is a prevalent and
debilitating condition. Deep brain stimulation to different targets has been proposed as a …

Subthalamic deep brain stimulation (DBS) for Parkinson disease (PD) currently requires
laborious open-loop programming, which can mitigate the benefits of this treatment …

Importance Patients with treatment-resistant depression (TRD) do not respond sufficiently to
several consecutive treatments for major depressive disorder. Deep brain stimulation (DBS) …

Object Deep brain stimulation (DBS) surgery is increasingly prominent in the treatment of
various disorders refractory to medication. Despite the procedure's efficacy, the community …

Deep brain stimulation (DBS) is a therapeutic option for intractable neurological and
psychiatric disorders, including Parkinson's disease and major depression. Because of the …

Cognitive abnormalities are a core feature of depression, and biases toward negatively
toned emotional information are common, but are they a cause or a consequence of …

Objective Alzheimer disease (AD) is characterized by functional impairment in the neural
elements and circuits underlying cognitive and memory functions. We hypothesized that …