Deep brain stimulation (DBS) is a new therapeutic approach for treatment-resistant
depression (TRD). There is a preliminary evidence of the efficacy and safety of DBS for TRD …

Stress can have a lasting impact on the structure and function of brain circuitry that results in
long-lasting changes in the behavior of an organism. Synaptic plasticity is the mechanism by …

The medial forebrain bundle (MFB), a key structure of reward-seeking circuitry, remains
inadequately characterized in humans despite its vast importance for emotional processing …

Rapid advancements in neurostimulation technologies are providing relief to an
unprecedented number of patients affected by debilitating neurologic and psychiatric …

Despite being considered primarily a mood disorder, major depressive disorder (MDD) is
characterized by cognitive and decision making deficits. Recent research has employed …

The development of advanced neuroimaging techniques and their deployment in large
cohorts has enabled an assessment of functional and structural brain network architecture at …

During the last 20 years of neuroscience research, we have witnessed a fundamental shift in
the conceptualization of psychiatric disorders, with the dominant psychological and …

Object Deep brain stimulation (DBS) has been recently investigated as a treatment for major
depression. One of the proposed targets for this application is the subcallosal cingulate …

Background How is happiness generated via brain function in lucky individuals who have
the good fortune to be happy? Conceptually, well-being or happiness has long been viewed …

Mood disorders cause significant morbidity and mortality, and existing therapies fail 20%–
30% of patients. Deep brain stimulation (DBS) is an emerging treatment for refractory mood …