The first reports of disorders that in terms of cognitive and behavioral symptoms resemble
frontotemporal dementia (FTD) and in terms of motor symptoms resemble amyotrophic …

Background Current practice for selecting pharmacological and non-pharmacological
antidepressant treatments has yielded low response and remission rates in Major …

Although rTMS is moving steadily into the mainstream as a treatment for medically refractory
depression, its efficacy continues to lag behind that of more invasive neuromodulation …

Medications, psychotherapy, and other treatments are effective for many patients with
psychiatric disorders. However, with currently available interventions, a substantial number …

Background The dorsolateral prefrontal cortex (DLPFC) is a common target for repetitive
transcranial magnetic stimulation (rTMS) in major depression, but the conventional “5 cm …

Background Stress-related disorders (eg, depression) are associated with hypothalamic-
pituitary-adrenocortical axis dysregulation and prefrontal cortex (PFC) dysfunction …

Background Anorexia nervosa is characterised by a chronic course that is refractory to
treatment in many patients and has one of the highest mortality rates of any psychiatric …

Much attention has been paid to the potential role of the immune system in the
pathophysiology of major depression in humans. While activation of innate immune …

Abstract Major Depressive Disorder (MDD) has been conceptualized as a neural network-
level disease. Few studies of the neural bases of depression, however, have used analytical …

Functional stereotaxy was introduced in the late 1940s to reduce the morbidity of lobotomy
in psychiatric disease by using more focal lesions. The advent of neuroleptics led to a drastic …