Histone post-translational modifications (HPTMs) are essential epigenetic mechanisms that
affect chromatin-associated nuclear processes without altering the DNA sequence. With the …

T cell subsets adapt and rewire their metabolism according to their functions and
surrounding microenvironment. Whereas naive T cells rely on mitochondrial metabolic …

The reversible post-translational modification (PTM) of proteins plays an important role in
many cellular processes. Lysine crotonylation (Kcr) is a newly identified PTM, but its …

During emergency hematopoiesis, hematopoietic stem cells (HSCs) rapidly proliferate to
produce myeloid and lymphoid effector cells, a response that is critical against infection or …

Neuroplasticity refers to the ability of brain circuits to reorganize and change the properties
of the network, resulting in alterations in brain function and behavior. It is traditionally …

Background Emerging evidence indicates that epigenetic modulation of gene expression
plays a key role in the progression of autosomal dominant polycystic kidney disease …

Epigenetic regulation is a process that takes place through adaptive cellular pathways
influenced by environmental factors and metabolic changes to modulate gene activity with …

Background Liver fibrosis is an independent contributor of chronic liver diseases, and
regressing liver fibrosis is considered a potential therapeutic target for chronic liver …

Protein post-translational modifications (PTMs) are important regulators of protein functions
and produce proteome complexity. SIRT1 has NAD+-dependent deacylation of acyl-lysine …

Histone lysine crotonylation was first identified as a new type of post-translational
modification in 2011. In recent years, prominent progress has been made in the study of …