Histone lysine crotonylation (KCR), a novel epigenetic modification, is important in
regulating a broad spectrum of biological processes and various diseases. However …

Protein post-translational modifications (PTMs) are important regulators of protein functions
and produce proteome complexity. SIRT1 has NAD+-dependent deacylation of acyl-lysine …

Drug addiction is a complex disease affected by numerous genetic and environmental
factors. Brain regions in reward pathway, neuronal adaptations, genetic and epigenetic …

Sirtuin 2 (SIRT2), as a member of the sirtuin family, has representative features of
evolutionarily highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent …

Background Liver fibrosis is an independent contributor of chronic liver diseases, and
regressing liver fibrosis is considered a potential therapeutic target for chronic liver …

The DNA damage response (DDR) system plays an important role in maintaining genome
stability and preventing related diseases. The DDR network comprises many proteins and …

Spermatogenesis is the process of generation of male reproductive cells from
spermatogonial stem cells in the seminiferous epithelium of the testis. During …

DNA is highly vulnerable to spontaneous and environmental timely damage in living cells.
DNA damage may cause genetic instability and increase cancer risk if the damages are not …

Short-chain fatty acids (SCFAs) are a subset of fatty acids that play crucial roles in
maintaining normal physiology and developing metabolic diseases, such as obesity …

In the past decade, significant advances in molecular research have provided a deeper
understanding of the intricate regulatory mechanisms involved in carcinogenesis …