Microbial composition, functionality, and stress resilience or susceptibility: unraveling sex-specific patterns

A Tanelian, B Nankova, M Miari, EL Sabban - Biology of sex Differences, 2024 - Springer
Background Following exposure to traumatic stress, women are twice as likely as men to
develop mood disorders. Yet, individual responses to such stress vary, with some people …

Histone Acyl Code in Precision Oncology: Mechanistic Insights from Dietary and Metabolic Factors

S Neja, WM Dashwood, RH Dashwood, P Rajendran - Nutrients, 2024 - mdpi.com
Cancer etiology involves complex interactions between genetic and non-genetic factors,
with epigenetic mechanisms serving as key regulators at multiple stages of pathogenesis …

An Overview of the Epigenetic Modifications in the Brain under Normal and Pathological Conditions

L Lossi, C Castagna, A Merighi - International Journal of Molecular …, 2024 - mdpi.com
Epigenetic changes are changes in gene expression that do not involve alterations to the
DNA sequence. These changes lead to establishing a so-called epigenetic code that …

[HTML][HTML] Decrotonylation of cGAS K254 prompts homologous recombination repair by blocking its DNA binding and releasing PARP1

H Guo, Y Han, S Yao, B Chen, H Zhao, J Jia… - Journal of Biological …, 2024 - Elsevier
Abstract Cyclic GMP-AMP synthase (cGAS), a cytosolic DNA sensor, also exhibits nuclear
genomic localization and is involved in DNA damage signaling. In this study, we …

NDUFA9 and its crotonylation modification promote browning of white adipocytes by activating mitochondrial function in mice

Y Liu, Z Liu, Z Ren, Q Han, X Chen, J Han, G Qiu… - … International Journal of …, 2024 - Elsevier
Protein crotonylation plays a role in regulating cellular metabolism, gene expression, and
other biological processes. NDUFA9 (NADH dehydrogenase [ubiquinone] 1 alpha …

Post‐translational modifications of proteins in cardiovascular diseases examined by proteomic approaches

M Stastna - The FEBS Journal, 2024 - Wiley Online Library
Over 400 different types of post‐translational modifications (PTMs) have been reported and
over 200 various types of PTMs have been discovered using mass spectrometry (MS) …

[HTML][HTML] Reading and erasing of histone crotonyllysine mimics by the AF9 YEATS domain and SIRT2 deacylase

N Bilgin, VA Türkmen, N Hammami… - Bioorganic & Medicinal …, 2023 - Elsevier
Lysine acylations on histones and their recognition by chromatin-binding reader domains
and removal by histone deacylases function as an important mechanism for eukaryotic gene …

[HTML][HTML] CHHM: a Manually Curated Catalogue of Human Histone Modifications Revealing Hotspot Regions and Unique Distribution Patterns

W Ma, X Ding, J Xu, TCW Poon - International Journal of Biological …, 2024 - ijbs.com
Histone modification is one of the key elements in epigenetic control and plays important
roles in regulation of biological processes and disease development. Currently, records of …

Histone crotonylation in neurobiology: to be or not to be?

C Deng, JH Qu, IK Kim, X Tang - Chinese Medical Journal, 2022 - journals.lww.com
Epigenetic regulation is a pivotal mechanism that controls gene transcription and cell fate.
During the past decades, it has been observed that histone, DNA, and RNA modifications …

Comprehensive Profiling of Paper Mulberry (Broussonetia papyrifera) Crotonylome Reveals the Significance of Lysine Crotonylation in Young Leaves

Y Dong, C Chen - International journal of molecular sciences, 2022 - mdpi.com
Lysine crotonylation is a newly discovered and reversible posttranslational modification
involved in various biological processes, especially metabolism regulation. A total of 5159 …