Schizophrenia is a major mental illness characterized by positive and negative symptoms,
and by cognitive deficit. Although cognitive impairment is disabling for patients, it has been …

Phosphodiesterases (PDEs) have been an interesting drug target for many diseases.
Although a vast number of mainly preclinical studies demonstrates beneficial effects of PDE …

Nowadays, facile and short synthesis of new antifungal pyrazole-derivatives ligands has
attracted increasing attention due to their simplicity and effectiveness. In here, we have …

Background Neuroinflammation plays a pivotal role in the pathogenesis of Parkinson's
disease (PD). Thus, the development of agents that can control neuroinflammation has been …

The cinnoline nucleus is a very important bicyclic heterocycle that is used as the structural
subunit of many compounds with interesting pharmaceutical properties. Cinnoline …

Multitarget drugs based on a hybrid dopamine–xanthine core were designed as potential
drug candidates for the treatment of neurodegenerative diseases. Monoamine oxidase B …

Background and Purpose—Many restorative therapies have been used to study brain repair
after stroke. These therapeutic-induced changes have revealed important insights on brain …

Pulmonary arterial hypertension (PAH) causes pathological increase in pulmonary vascular
resistance, leading to right-heart failure and eventual death. Previously, phosphodiesterase …

Microglial priming is the process of microglial proliferation and activation in response to
neurodegeneration and abnormal protein accumulation. Priming makes microglia …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor
impairments. Most PD drugs act by improving motor impairments, whereas very few drugs …