Increases in cancer diagnosis have tremendous negative impacts on patients and their
families, and major societal and economic costs. The beneficial effect of chemotherapeutic …

In 2000, the American Society of Interventional Pain Physicians (ASIPP) created treatment
guidelines to help practitioners. There have been 5 subsequent updates. These guidelines …

Sativex, a cannabinoid extract with a 1: 1 ratio of tetrahydocannabinol and cannabidiol, has
been shown to alleviate neuropathic pain associated with chemotherapy. This research …

Antibody-based methods for the detection and quantification of membrane integral proteins,
in particular, the G protein-coupled receptors (GPCRs), have been plagued with issues of …

The analgesic effects of cannabinoid ligands, mediated by CB1 receptors are well
established. However, the side-effect profile of CB1 receptor ligands has necessitated the …

Introduction Targeting CB2 cannabinoid receptor (CB2r) represents a promising approach
for the treatment of central nervous system disorders. These receptors were identified in …

Background More evidence suggests that dorsal spinal cord microglia is an important site
contributing to CB2 receptor-mediated analgesia. The upregulation of P2Y 12 and P2Y 13 …

Cannabis is one of the oldest and widely used substances in the world. Cannabinoids within
the cannabis plant, known as phytocannabinoids, mediate cannabis9 effects through …

Endometriosis, a chronic condition affecting around 10–14% of women, is challenging to
manage, due to its complex pathogenesis and limited treatment options. Research has …

Pain is a worldwide public health problem and its treatment is still a challenge since
clinically available drugs do not completely reverse chronic painful states or induce …