North Africa is defined as the geographical region separated from the rest of the continent by
the Sahara and from Europe by the Mediterranean Sea. The main demographic features of …

The field of germline genetic testing for breast cancer (BC) risk has evolved substantially in
the last decade. The introduction of multigene panel testing (MGPT) led to an urgent need to …

Importance To date, few studies have examined the extent to which polygenic single-
nucleotide variation (SNV)(formerly single-nucleotide polymorphism) scores modify risk for …

PURPOSE This study assessed the joint association of pathogenic variants (PVs) in breast
cancer (BC) predisposition genes and polygenic risk scores (PRS) with BC in the general …

Background The relationship between germline genetic variation and breast cancer survival
is largely unknown, especially in understudied minority populations who often have poorer …

Our study describes breast cancer risk loci using a cross-ancestry GWAS approach. We first
identify variants that are associated with breast cancer at P< 0.05 from African ancestry …

We conducted this study to explore the association between matrix metalloproteinase (MMP)
gene polymorphisms and breast cancer (BC) risk in the Caucasian women of Russia. In …

Background More than 180 single nucleotide polymorphisms (SNPs) associated with breast
cancer susceptibility have been identified; these SNPs can be combined into polygenic risk …

Background Distinct prevalence of inherited genetic predisposition may partially explain the
difference of cancer risks across ancestries. Ancestry-specific analyses of germline …

OBJECTIVE. Dense breast tissue is an established risk factor for the development of breast
cancer. Methods for reliable and reproducible identification of breast density have been …