Highlights•The glycolipid Lipid A is the conserved, amphipathic moiety of LPS.•Lipid A binds
to certain Toll like receptors and caspases with high affinity.•Bacteria alter their Lipid A …

3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) 2-lipid A is the conserved structure domain of
lipopolysaccharide found in most Gram-negative bacteria, and it is believed to stimulate the …

Neisseria meningitidis contains a very potent hexa-acylated LPS that is too toxic for
therapeutic applications. We used systematic molecular bioengineering of meningococcal …

Helicobacter pylori produces a unique surface lipopolysaccharide (LPS) characterized by
strikingly low endotoxicity that is thought to aid the organism in evading the host immune …

We need new treatment options to control bacterial infections. Bacteria use several
strategies to resist drug treatment, including modification of the drug target, and adaptation …

Monophosphoryl lipid A (MPLA) species, including MPL (a trade name of GlaxoSmithKline)
and GLA (a trade name of Immune Design, a subsidiary of Merck), are widely used as an …

We report on comprehensive structure characterization of lipid A extracted from Yersinia
pestis (Yp) for determination of its phosphorylation configuration that was achieved by …

Vibrio parahaemolyticus is a foodborne pathogen and naturally resistant to polymyxins, the
last line of therapy for infections caused by multidrug-resistant bacteria. Polymyxins …

The core-lipid A domain of Escherichia coli lipopolysaccharide (LPS) is synthesized on the
inner surface of the inner membrane (IM) and flipped to its outer surface by the ABC …

Although distinct lipid phosphatases are thought to be required for processing lipid A
(component of the outer leaflet of the outer membrane), glycerophospholipid (component of …