In many solid tumor types, tumor-associated macrophages (TAMs) are important
components of the tumor microenvironment (TME). Moreover, TAMs infiltration is strongly …

Macrophages are phagocytic sentinel cells of the immune system that are central to both
innate and adaptive immune responses and serve as the first line of defense against …

Background Dihydroartemisinin (DHA) has been shown to exert anticancer activity through
iron-dependent reactive oxygen species (ROS) generation, which is similar to ferroptosis, a …

Myeloid cells infiltrating tumors are gaining ever growing attention in the last years because
their pro-tumor and immunosuppressive functions are relevant for disease progression and …

Nuclear receptors are intracellular proteins that act as transcription factors. Proteins with
classic nuclear receptor domain structure lacking identified signaling ligands are designated …

In the last decade, it has been well-established that tumor-infiltrating myeloid cells fuel not
only the process of carcinogenesis through cancer-related inflammation mechanisms, but …

Emerging evidence has indicated that microRNAs are involved in multiple processes of
cancer development. Previous studies have demonstrated that microRNA-499a (miR-499a) …

Copper is involved in various biochemical and physiological processes. The absorbed
copper ions are transported to the intracellular destination via copper chaperones, such as …

The DNA damage response (DDR) is necessary to maintain genome integrity and prevent
the accumulation of oncogenic mutations. Consequently, proteins involved in the DDR often …

Summary Mediator kinases (CDK8/19) are transcriptional regulators broadly implicated in
cancer. Despite their central role in fine-tuning gene-expression programs, we find complete …