[HTML][HTML] Communication in the cancer microenvironment as a target for therapeutic interventions
A Dominiak, B Chełstowska, W Olejarz, G Nowicka - Cancers, 2020 - mdpi.com
The tumor microenvironment (TME) is a complex system composed of multiple cells, such as
non-cancerous fibroblasts, adipocytes, immune and vascular cells, as well as signal …
non-cancerous fibroblasts, adipocytes, immune and vascular cells, as well as signal …
Hepatocellular carcinoma mechanisms associated with chronic HCV infection and the impact of direct-acting antiviral treatment
S Dash, Y Aydin, KE Widmer… - Journal of hepatocellular …, 2020 - Taylor & Francis
Hepatitis C virus (HCV) infection is the major risk factor for liver cirrhosis and hepatocellular
carcinoma (HCC). The mechanisms of HCC initiation, growth, and metastasis appear to be …
carcinoma (HCC). The mechanisms of HCC initiation, growth, and metastasis appear to be …
[HTML][HTML] Therapy-induced evolution of human lung cancer revealed by single-cell RNA sequencing
Lung cancer, the leading cause of cancer mortality, exhibits heterogeneity that enables
adaptability, limits therapeutic success, and remains incompletely understood. Single-cell …
adaptability, limits therapeutic success, and remains incompletely understood. Single-cell …
[HTML][HTML] Conformational changes in the human Cx43/GJA1 gap junction channel visualized using cryo-EM
Connexin family proteins assemble into hexameric hemichannels in the cell membrane. The
hemichannels dock together between two adjacent membranes to form gap junction …
hemichannels dock together between two adjacent membranes to form gap junction …
[HTML][HTML] Glioblastoma microenvironment and cellular interactions
Simple Summary This paper summarizes the crosstalk between tumor/non-tumor cells and
other elements of the glioblastoma (GB) microenvironment. In tumor pathology, glial cells …
other elements of the glioblastoma (GB) microenvironment. In tumor pathology, glial cells …
Nerve input to tumours: Pathophysiological consequences of a dynamic relationship
C Hutchings, JA Phillips, MBA Djamgoz - Biochimica et Biophysica Acta …, 2020 - Elsevier
It is well known that tumours arising in different organs are innervated and that 'perineural
invasion'(cancer cells escaping from the tumour by following the nerve trunk) is a negative …
invasion'(cancer cells escaping from the tumour by following the nerve trunk) is a negative …
Structures of wild-type and selected CMT1X mutant connexin 32 gap junction channels and hemichannels
In myelinating Schwann cells, connection between myelin layers is mediated by gap
junction channels (GJCs) formed by docked connexin 32 (Cx32) hemichannels (HCs) …
junction channels (GJCs) formed by docked connexin 32 (Cx32) hemichannels (HCs) …
Mechanisms and strategies to enhance penetration during intravesical drug therapy for bladder cancer
P Zhang, G Wu, D Zhang, WF Lai - Journal of Controlled Release, 2023 - Elsevier
Bladder cancer (BCa) is one of the most prevalent cancers worldwide. The effectiveness of
intravesical therapy for bladder cancer, however, is limited due to the short dwell time and …
intravesical therapy for bladder cancer, however, is limited due to the short dwell time and …
In silico approaches in carcinogenicity hazard assessment: current status and future needs
RR Tice, A Bassan, A Amberg, LT Anger… - Computational …, 2021 - Elsevier
Historically, identifying carcinogens has relied primarily on tumor studies in rodents, which
require enormous resources in both money and time. In silico models have been developed …
require enormous resources in both money and time. In silico models have been developed …
Connexin and gap junctions: perspectives from biology to nanotechnology based therapeutics
S Jindal, S Chockalingam, SS Ghosh… - Translational …, 2021 - Elsevier
The concept of gap junctions and their role in intercellular communication has been known
for around 50 years. Considerable progress has been made in understanding the …
for around 50 years. Considerable progress has been made in understanding the …